Heterotopic Ossification and Hypertrophic Scars

Overview

Journal Clin Plast Surg

Specialty General Surgery

Date 2017 Sep 11

PMID 28888300

Citations 14

Authors

Shailesh Agarwal

Michael Sorkin

Benjamin Levi

Affiliations

Soon will be listed here.

Abstract

Burns and trauma cause superficial and deep soft tissue wounds that cannot heal to the preinjury state. Healing requires cell proliferation and differentiation into the injured tissue type, laying down extracellular matrix, often as collagens. Heterotopic ossification causes severe pain, nonhealing wounds, and restricted range of motion. Treatment includes radiation therapy, nonsteroidal anti-inflammatory drugs, bisphosphonates, and possibly surgical excision and prophylactic measures. Hypertrophic scars, nonosseous lesions caused by excessive collagen deposition, are often painful, functionally limiting, and aesthetically displeasing. Treatment includes CO2 laser application, steroid injections, and excision with skin grafting. This article reviews the management of these pathologic wounds.

Citing Articles

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PMID: 38594791 PMC: 11004040. DOI: 10.1002/jev2.12425.

Physical and psychosocial outcomes among burn-injured people with heterotopic ossification: A burn model system study.

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Enhanced BMP signaling in Cathepsin K-positive tendon progenitors induces heterotopic ossification.

Yamaguchi H, Li M, Kitami M, Swaminathan S, Mishina Y, Komatsu Y Biochem Biophys Res Commun. 2023; 688:149147.

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Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro.

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