Towards Human Exploration of Space: The THESEUS Review Series on Immunology Research Priorities

Overview

Journal NPJ Microgravity

Publisher Springer Nature

Date 2017 Jul 21

PMID 28725745

Citations 45

Authors

Jean-Pol Frippiat

Brian E Crucian

Dominique J-F de Quervain

Daniela Grimm

Nicola Montano

Siegfried Praun

Benno Roozendaal

Gustav Schelling

Manfred Thiel

Oliver Ullrich

Alexander Chouker

Affiliations

Soon will be listed here.

Abstract

Dysregulation of the immune system occurs during spaceflight and may represent a crew health risk during exploration missions because astronauts are challenged by many stressors. Therefore, it is crucial to understand the biology of immune modulation under spaceflight conditions in order to be able to maintain immune homeostasis under such challenges. In the framework of the THESEUS project whose aim was to develop an integrated life sciences research roadmap regarding human space exploration, experts working in the field of space immunology, and related disciplines, established a questionnaire sent to scientists around the world. From the review of collected answers, they deduced a list of key issues and provided several recommendations such as a maximal exploitation of currently available resources on Earth and in space, and to increase increments duration for some ISS crew members to 12 months or longer. These recommendations should contribute to improve our knowledge about spaceflight effects on the immune system and the development of countermeasures that, beyond astronauts, could have a societal impact.

Citing Articles

Simulated microgravity impairs human NK cell cytotoxic activity against space radiation-relevant leukemic cells.

Kuhlman B, Diaz J, Simon T, Reeves K, Walker S, Atala A NPJ Microgravity. 2024; 10(1):85.

PMID: 39143086 PMC: 11324864. DOI: 10.1038/s41526-024-00424-1.

Considerations for oral and dental tissues in holistic care during long-haul space flights.

Bakr M, Caswell G, Hussein H, Shamel M, Al-Ankily M Front Physiol. 2024; 15:1406631.

PMID: 39055690 PMC: 11269229. DOI: 10.3389/fphys.2024.1406631.

Lost in Space? Unmasking the T Cell Reaction to Simulated Space Stressors.

Miranda S, Vermeesen R, Radstake W, Parisi A, Ivanova A, Baatout S Int J Mol Sci. 2023; 24(23).

PMID: 38069265 PMC: 10707245. DOI: 10.3390/ijms242316943.

Hindlimb unloading, a physiological model of microgravity, modifies the murine bone marrow IgM repertoire in a similar manner as aging but less strongly.

Fonte C, Jacob P, Vanet A, Ghislin S, Frippiat J Immun Ageing. 2023; 20(1):64.

PMID: 37986079 PMC: 10659048. DOI: 10.1186/s12979-023-00393-1.

The Impact of Microgravity on Immunological States.

Hicks J, Olson M, Mitchell C, Juran C, Paul A Immunohorizons. 2023; 7(10):670-682.

PMID: 37855736 PMC: 10615652. DOI: 10.4049/immunohorizons.2200063.

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