Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains

Overview

Journal Sci Rep

Specialty Science

Date 2017 Jul 14

PMID 28701762

Citations 11

Authors

Ewan P Plant

Lucy J Fredell

Blake A Hatcher

Xing Li

Meng-Jung Chiang

Martina Kosikova

Hang Xie

Olga Zoueva

Angelia A Cost

Zhiping Ye

Michael J Cooper

Affiliations

Soon will be listed here.

Abstract

Seasonal influenza vaccine formulas change almost every year yet information about how this affects the antibody repertoire of vaccine recipients is inadequate. New vaccine virus strains are selected, replacing older strains to better match the currently circulating strains. But even while the vaccine is being manufactured the circulating strains can evolve. The ideal response to a seasonal vaccine would maintain antibodies toward existing strains that might continue to circulate, and to generate cross-reactive antibodies, particularly towards conserved influenza epitopes, potentially limiting infections caused by newly evolving strains. Here we use the hemagglutination inhibition assay to analyze the antibody repertoire in subjects vaccinated two years in a row with either identical vaccine virus strains or with differing vaccine virus strains. The data indicates that changing the vaccine formulation results in an antibody repertoire that is better able to react with strains emerging after the vaccine virus strains are selected. The effect is observed for both influenza A and B strains in groups of subjects vaccinated in three different seasons. Analyses include stratification by age and sex.

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