Influenza Vaccination of Pregnant Women Protects Them over Two Consecutive Influenza Seasons in a Randomized Controlled Trial

Overview

Journal Expert Rev Vaccines

Date 2016 May 24

PMID 27212228

Citations 13

Authors

Eleonora Mutsaerts

Shabir A Madhi

Clare L Cutland

Stephanie Jones

Andrea Hugo

Siobhan Trenor

Florette K Treurnicht

Kerstin Klipstein-Grobusch

Adriana Weinberg

Marta C Nunes

Affiliations

Soon will be listed here.

Abstract

Background: We assessed the persistence of hemagglutinin inhibition (HAI) antibodies and the vaccine efficacy (VE) of trivalent inactivated influenza vaccine (IIV3) following vaccination of a cohort of pregnant South African women during a second influenza season.

Methods: A cohort of women who participated in a randomized placebo-controlled trial on the safety, immunogenicity and efficacy of IIV3 in 2011 had HAI titers measured in 2012 and were monitored for influenza illness until the end of 2012.

Results: The proportion of women with HAI titers ≥1:40 was significantly greater in vaccinees (63%) compared to placebo-recipients (22%; p < 0.001). VE in 2012 was 63.8% (95% confidence interval [95%CI]: -33.7%, 90.2%); combined VE for 2011 and 2012 was 58.3% (95%CI: 0.2%, 82.6%).

Conclusion: The majority of women who received IIV3 during pregnancy had HAI titers above the putative threshold for protection against influenza illness one year after vaccination and showed a trend towards protection against influenza disease.

Citing Articles

Serological Responses to Influenza Vaccination during Pregnancy.

Vazquez-Pagan A, Schultz-Cherry S Microorganisms. 2021; 9(11).

PMID: 34835431 PMC: 8619416. DOI: 10.3390/microorganisms9112305.

The epidemiology of seasonal influenza after the 2009 influenza pandemic in Africa: a systematic review.

Lagare A, Rajatonirina S, Testa J, Mamadou S Afr Health Sci. 2021; 20(4):1514-1536.

PMID: 34394213 PMC: 8351825. DOI: 10.4314/ahs.v20i4.5.

Knowledge, attitudes, and practices of seasonal influenza vaccination in postpartum women, Honduras.

Madewell Z, Chacon-Fuentes R, Jara J, Mejia-Santos H, Molina I, Alvis-Estrada J PLoS One. 2021; 16(2):e0246385.

PMID: 33571256 PMC: 7877664. DOI: 10.1371/journal.pone.0246385.

Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials.

Omer S, Clark D, Madhi S, Tapia M, Nunes M, Cutland C Lancet Respir Med. 2020; 8(6):597-608.

PMID: 32526188 PMC: 7284303. DOI: 10.1016/S2213-2600(19)30479-5.

Vertically Transferred Immunity in Neonates: Mothers, Mechanisms and Mediators.

Albrecht M, Arck P Front Immunol. 2020; 11:555.

PMID: 32296443 PMC: 7136470. DOI: 10.3389/fimmu.2020.00555.

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