Implications of Antimicrobial Combinations in Complex Wound Biofilms Containing Fungi

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2017 Jul 12

PMID 28696230

Citations 18

Authors

Eleanor M Townsend

Leighann Sherry

Ryan Kean

Donald Hansom

William G Mackay

Craig Williams

John Butcher

Gordon Ramage

Affiliations

Soon will be listed here.

Abstract

Diabetic foot ulcer treatment currently focuses on targeting bacterial biofilms, while dismissing fungi. To investigate this, we used an biofilm model containing bacteria and fungi, reflective of the wound environment, to test the impact of antimicrobials. Here we showed that while monotreatment approaches influenced biofilm composition, this had no discernible effect on overall quantity. Only by combining bacterium- and fungus-specific antibiotics were we able to decrease the biofilm bioburden, irrespective of composition.

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