Impact of Oocytes with CLCG on ICSI Outcomes and Their Potential Relation to Pesticide Exposure

Overview

Journal J Ovarian Res

Publisher Biomed Central

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2017 Jul 12

PMID 28693528

Citations 14

Authors

Philippe Merviel

Rosalie Cabry

Karen Chardon

Elodie Haraux

Florence Scheffler

Naima-Belhadri Mansouri

Aviva Devaux

Hikmat Chahine

Veronique Bach

Henri Copin

Moncef Benkhalifa

Affiliations

Soon will be listed here.

Abstract

Background: Oocyte quality is a key limiting factor in female fertility which is primarily reflected in morphological features. Centrally located cytoplasm granulation (CLCG) is one type of cytoplasmic dimorphism exhibited by oocytes that could be linked to pesticide exposure with a significant risk of decreased ICSI outcomes.

Methods: This retrospective study included 633 women who were part of an intracytoplasmic spermatozoa injection (ICSI) program between 2009 and 2011. The participants lived in the Picardy region of France and had been exposed to pesticides. The participants were divided in two groups based on prevalence of oocytes with CLCG (LCLCG [n = 83]: low prevalence of oocytes with CLCG under 25%. HCLCG [n = 68]: high prevalence of CLCG over 75%). The embryological and clinical outcomes were analysed for both groups and were calculated using the difference between the two values.

Results: Results for couples with HCLCG compared to LCLCG showed a decrease in embryo cleavage, ongoing pregnancy, and live birth rates (82%, 14%, 13% vs 99%, 32%, 30%, respectively).The early miscarriage rate was increased (47% vs 11%), with an OR of 3.1 (95%CI [2.1-4.1]). Due to high pesticide exposure (over 3000 g/ha), there is a higher risk of a resulting disturbed oocyte cohort with a high prevalence of CLCG over 75%.

Conclusion: The high prevalence of oocytes with CLCG over 75% has a negative effect on embryos and the general ICSI clinical outcomes. Furthermore, a putative association between pesticide exposure and risk of CLCG was identified, justifying the need for further research and a potential need to find alternative assisted reproductive technologies for these couples.

Trial Registration: Tabacfertimasc. ID number: ID2011-A00634-37 ; registered 2011/2/8.

Citing Articles

Endocrine disruptor chemicals exposure and female fertility declining: from pathophysiology to epigenetic risks.

Tricotteaux-Zarqaoui S, Lahimer M, Abou Diwan M, Corona A, Candela P, Cabry R Front Public Health. 2024; 12:1466967.

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Mature oocyte dysmorphisms may be associated with progesterone levels, mitochondrial DNA content, and vitality in luteal granulosa cells.

Raad G, Tanios J, Serdarogullari M, Bazzi M, Mourad Y, Azoury J J Assist Reprod Genet. 2024; 41(3):795-813.

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Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.

Lahimer M, Abou Diwan M, Montjean D, Cabry R, Bach V, Ajina M Front Public Health. 2023; 11:1232646.

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Lahimer M, Djekkoun N, Tricotteaux-Zarqaoui S, Corona A, Lafosse I, Ben Ali H Toxics. 2023; 11(9).

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The Molecular Quality and Mitochondrial Activity of Porcine Cumulus-Oocyte Complexes Are Affected by Their Exposure to Three Endocrine-Active Compounds under 3D In Vitro Maturation Conditions.

Gorczyca G, Wartalski K, Romek M, Samiec M, Duda M Int J Mol Sci. 2022; 23(9).

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