The Impact of Endocrine Disruptor Chemicals on Oocyte/embryo and Clinical Outcomes in IVF

Overview

Journal Endocr Connect

Specialty Endocrinology

Date 2020 May 8

PMID 32380469

Citations 11

Authors

Rosalie Cabry

Philippe Merviel

Aicha Madkour

Elodie Lefranc

Florence Scheffler

Rachel Desailloud

Veronique Bach

Moncef Benkhalifa

Affiliations

Soon will be listed here.

Abstract

The negative impact of endocrine-disrupting pesticides on human fertility is now a key issue in reproductive health. There are much fewer literature data about the impact of pesticide exposure on women than on men and very few studies of women participating in an in vitro fertilization (IVF) programme. In the present review, we found that (1) various pesticides with an endocrine-disrupting action are associated with poor oocyte maturation and competency, embryonic defects and poor IVF outcomes, and (2) some pesticide compounds are linked to specific causes of female infertility, such as premature ovarian insufficiency, polycystic ovarian syndrome, and endometriosis. IVF participants living in agricultural regions should be informed about the fertility decline, low ongoing pregnancy rates, and elevated risk of miscarriage associated with exposure to high doses of pesticides.

Citing Articles

Endocrine disruptor chemicals exposure and female fertility declining: from pathophysiology to epigenetic risks.

Tricotteaux-Zarqaoui S, Lahimer M, Abou Diwan M, Corona A, Candela P, Cabry R Front Public Health. 2024; 12:1466967.

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Which is the current knowledge on man-made endocrine- disrupting chemicals in follicular fluid? An overview of effects on ovarian function and reproductive health.

Shulhai A, Bianco V, Donini V, Esposito S, Street M Front Endocrinol (Lausanne). 2024; 15:1435121.

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Endocrine disrupting chemicals and male fertility: from physiological to molecular effects.

Lahimer M, Abou Diwan M, Montjean D, Cabry R, Bach V, Ajina M Front Public Health. 2023; 11:1232646.

PMID: 37886048 PMC: 10598475. DOI: 10.3389/fpubh.2023.1232646.

Long-Term Effects of ART on the Health of the Offspring.

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Ultrastructural Evaluation of Mouse Oocytes Exposed In Vitro to Different Concentrations of the Fungicide Mancozeb.

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