Thoughts on the Popularity of ICSI

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2020 Nov 6

PMID 33155089

Citations 22

Authors

Mounia Haddad

Joshua Stewart

Philip Xie

Stephanie Cheung

Aysha Trout

Derek Keating

Alessandra Parrella

Sherina Lawrence

Zev Rosenwaks

Gianpiero D Palermo

Affiliations

Soon will be listed here.

Abstract

Purpose: Intracytoplasmic sperm injection (ICSI) is the most widely utilized assisted reproductive technique (ART) worldwide. In this feature, we review the early assisted fertilization attempts that eventually led to the development of ICSI, and discuss its current utilization in cases of male and non-male factor infertility.

Methods: We researched the literature related to the development, indications, and current use of ICSI, such as sperm structural abnormalities, male genetic indications, surgically retrieved sperm, high sperm chromatin fragmentation, oocyte dysmorphism, and preimplantation genetic testing (PGT). We also describe the potential future applications of ICSI.

Results: This review summarizes the early micromanipulation techniques that led to the inception of ICSI. We also explore its current indications, including non-male factor infertility, where its use is more controversial. Finally, we consider the benefits of future advancements in reproductive biology that may incorporate ICSI, such as in vitro spermatogenesis, neogametogenesis, and heritable genome editing.

Conclusion: The versatility, consistency, and reliability of ICSI have made it the most prevalently utilized ART procedure worldwide.

Citing Articles

Egg Cryopreservation for Social Reasons-A Literature Review.

Kynigopoulou S, Matsas A, Tsarna E, Christopoulou S, Panagopoulos P, Bakas P Healthcare (Basel). 2024; 12(23).

PMID: 39685043 PMC: 11641124. DOI: 10.3390/healthcare12232421.

Risk Factors for Prematurity and Congenital Malformations in Assisted Reproductive Technology Pregnancies-A Retrospective Study.

Tocariu R, Dinulescu A, Prejmereanu A, Maier C, Coricovac A, Archir E J Clin Med. 2024; 13(21).

PMID: 39518609 PMC: 11546360. DOI: 10.3390/jcm13216470.

Male Reproduction in Spinal Muscular Atrophy (SMA) and the Potential Impact of Oral Survival of Motor Neuron 2 (SMN2) Pre-mRNA Splicing Modifiers.

Bar-Chama N, Elsheikh B, Hewamadduma C, Guittari C, Gorni K, Mueller L Neurol Ther. 2024; 13(4):933-947.

PMID: 38750391 PMC: 11263299. DOI: 10.1007/s40120-024-00626-5.

Lower developmental potential of rat zygotes produced by ooplasmic injection of testicular spermatozoa versus cauda epididymal spermatozoa.

Ide M, Saito I, Sanbo M, Kanatsu-Shinohara M, Shinohara T, Hirabayashi M J Reprod Dev. 2024; 70(4):254-258.

PMID: 38735740 PMC: 11310386. DOI: 10.1262/jrd.2024-030.

Automated Single-Sperm Selection Software (SiD) during ICSI: A Prospective Sibling Oocyte Evaluation.

Montjean D, Godin Page M, Pacios C, Calve A, Hamiche G, Benkhalifa M Med Sci (Basel). 2024; 12(2).

PMID: 38651413 PMC: 11036211. DOI: 10.3390/medsci12020019.

References

Adamson G, de Mouzon J, Chambers G, Zegers-Hochschild F, Mansour R, Ishihara O . International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2011. Fertil Steril. 2018; 110(6):1067-1080. DOI: 10.1016/j.fertnstert.2018.06.039. View

Wang J, Sauer M . In vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement. Ther Clin Risk Manag. 2008; 2(4):355-64. PMC: 1936357. DOI: 10.2147/tcrm.2006.2.4.355. View

Edwards R, STEPTOE P . Current status of in-vitro fertilisation and implantation of human embryos. Lancet. 1983; 2(8362):1265-9. DOI: 10.1016/s0140-6736(83)91148-0. View

Asch R, Ellsworth L, Balmaceda J, Wong P . Pregnancy after translaparoscopic gamete intrafallopian transfer. Lancet. 1984; 2(8410):1034-5. DOI: 10.1016/s0140-6736(84)91127-9. View

Hamori M, Stuckensen J, Rumpf D, Kniewald T, Kniewald A, Marquez M . Zygote intrafallopian transfer (ZIFT): evaluation of 42 cases. Fertil Steril. 1988; 50(3):519-21. DOI: 10.1016/s0015-0282(16)60145-0. View

Cohen J, Edwards R, Fehilly C, Fishel S, Hewitt J, Purdy J . In vitro fertilization: a treatment for male infertility. Fertil Steril. 1985; 43(3):422-32. DOI: 10.1016/s0015-0282(16)48443-8. View

Svalander P, Wikland M, Jakobsson A, Forsberg A . Subzonal insemination (SUZI) or in vitro fertilization (IVF) in microdroplets for the treatment of male-factor infertility. J Assist Reprod Genet. 1994; 11(3):149-55. DOI: 10.1007/BF02332092. View

Kiessling A, Loutradis D, McShane P, Jackson K . Fertilization in trypsin-treated oocytes. Ann N Y Acad Sci. 1988; 541:614-20. DOI: 10.1111/j.1749-6632.1988.tb22298.x. View

Gordon J, Grunfeld L, Garrisi G, Talansky B, Richards C, Laufer N . Fertilization of human oocytes by sperm from infertile males after zona pellucida drilling. Fertil Steril. 1988; 50(1):68-73. DOI: 10.1016/s0015-0282(16)60010-9. View

10.

Gordon J, Talansky B . Assisted fertilization by zona drilling: a mouse model for correction of oligospermia. J Exp Zool. 1986; 239(3):347-54. DOI: 10.1002/jez.1402390306. View

11.

Tucker M, Bishop F, Cohen J, Wiker S, Wright G . Routine application of partial zona dissection for male factor infertility. Hum Reprod. 1991; 6(5):676-81. DOI: 10.1093/oxfordjournals.humrep.a137405. View

12.

Fishel S, Timson J, Lisi F, Rinaldi L . Evaluation of 225 patients undergoing subzonal insemination for the procurement of fertilization in vitro. Fertil Steril. 1992; 57(4):840-9. DOI: 10.1016/s0015-0282(16)54968-1. View

13.

Palermo G, Joris H, Devroey P, van Steirteghem A . Induction of acrosome reaction in human spermatozoa used for subzonal insemination. Hum Reprod. 1992; 7(2):248-54. DOI: 10.1093/oxfordjournals.humrep.a137626. View

14.

Yanagimachi R, Noda Y . Physiological changes in the postnuclear cap region of mammalian spermatozoa: a necessary preliminary to the membrane fusion between sperm and egg cells. J Ultrastruct Res. 1970; 31(5-6):486-93. DOI: 10.1016/s0022-5320(70)90164-4. View

15.

Hiramoto Y . An analysis of the mechanism of fertilation by means of enucleation of sea urchin eggs. Exp Cell Res. 1962; 28:323-34. DOI: 10.1016/0014-4827(62)90286-0. View

16.

Hiramoto Y . Microinjection of the live spermatozoa into sea urchin eggs. Exp Cell Res. 1962; 27:416-26. DOI: 10.1016/0014-4827(62)90006-x. View

17.

Uehara T, Yanagimachi R . Activation of hamster eggs by pricking. J Exp Zool. 1977; 199(2):269-74. DOI: 10.1002/jez.1401990211. View

18.

Uehara T, Yanagimachi R . Behavior of nuclei of testicular, caput and cauda epididymal spermatozoa injected into hamster eggs. Biol Reprod. 1977; 16(3):315-21. DOI: 10.1095/biolreprod16.3.315. View

19.

Iritani A, Utsumi K, Miyake M, Hosoi Y, Saeki K . In vitro fertilization by a routine method and by micromanipulation. Ann N Y Acad Sci. 1988; 541:583-90. DOI: 10.1111/j.1749-6632.1988.tb22295.x. View

20.

Goto K, Kinoshita A, Takuma Y, Ogawa K . Fertilisation of bovine oocytes by the injection of immobilised, killed spermatozoa. Vet Rec. 1990; 127(21):517-20. View