Antagonistic Modulation of NPY/AgRP and POMC Neurons in the Arcuate Nucleus by Noradrenalin

Overview

Journal Elife

Specialty Biology

Date 2017 Jun 21

PMID 28632132

Citations 17

Authors

Lars Paeger

Ismene Karakasilioti

Janine Altmuller

Peter Frommolt

Jens Bruning

Peter Kloppenburg

Affiliations

Soon will be listed here.

Abstract

In the arcuate nucleus of the hypothalamus (ARH) satiety signaling (anorexigenic) pro-opiomelanocortin (POMC)-expressing and hunger signaling (orexigenic) agouti-related peptide (AgRP)-expressing neurons are key components of the neuronal circuits that control food intake and energy homeostasis. Here, we assessed whether the catecholamine noradrenalin directly modulates the activity of these neurons in mice. Perforated patch clamp recordings showed that noradrenalin changes the activity of these functionally antagonistic neurons in opposite ways, increasing the activity of the orexigenic NPY/AgRP neurons and decreasing the activity of the anorexigenic POMC neurons. Cell type-specific transcriptomics and pharmacological experiments revealed that the opposing effect on these neurons is mediated by the activation of excitatory α - and β- adrenergic receptors in NPY/AgRP neurons, while POMC neurons are inhibited via α - adrenergic receptors. Thus, the coordinated differential modulation of the key hypothalamic neurons in control of energy homeostasis assigns noradrenalin an important role to promote feeding.

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