Neuronal Circuits That Regulate Feeding Behavior and Metabolism

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2013 Jun 25

PMID 23790727

Citations 126

Authors

Jong-Woo Sohn

Joel K Elmquist

Kevin W Williams

Affiliations

Soon will be listed here.

Abstract

Neurons within the central nervous system receive humoral and central (neurotransmitter or neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent advances in mouse genetics combined with neuroanatomical and electrophysiological techniques have contributed to a better understanding of these central mechanisms. This review integrates recently defined cellular mechanisms and neural circuits relevant to the regulation of feeding behavior, energy expenditure, and glucose homeostasis by metabolic signals.

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References

Liu T, Kong D, Shah B, Ye C, Koda S, Saunders A . Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 2012; 73(3):511-22. PMC: 3278709. DOI: 10.1016/j.neuron.2011.11.027. View

Marsh D, Hollopeter G, Kafer K, Palmiter R . Role of the Y5 neuropeptide Y receptor in feeding and obesity. Nat Med. 1998; 4(6):718-21. DOI: 10.1038/nm0698-718. View

Halatchev I, Ellacott K, Fan W, Cone R . Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism. Endocrinology. 2004; 145(6):2585-90. DOI: 10.1210/en.2003-1754. View

Tecott L, Sun L, Akana S, Strack A, Lowenstein D, Dallman M . Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 1995; 374(6522):542-6. DOI: 10.1038/374542a0. View

Coleman D . Effects of parabiosis of obese with diabetes and normal mice. Diabetologia. 1973; 9(4):294-8. DOI: 10.1007/BF01221857. View

Halford J, Boyland E, Blundell J, Kirkham T, Harrold J . Pharmacological management of appetite expression in obesity. Nat Rev Endocrinol. 2010; 6(5):255-69. DOI: 10.1038/nrendo.2010.19. View

Fu L, Acuna-Goycolea C, van den Pol A . Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004; 24(40):8741-51. PMC: 6729969. DOI: 10.1523/JNEUROSCI.2268-04.2004. View

Baldock P, Allison S, Lundberg P, Lee N, Slack K, Lin E . Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis. J Biol Chem. 2007; 282(26):19092-102. DOI: 10.1074/jbc.M700644200. View

Ghamari-Langroudi M, Colmers W, Cone R . PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors. Cell Metab. 2005; 2(3):191-9. DOI: 10.1016/j.cmet.2005.08.003. View

10.

Zhang G, Bai H, Zhang H, Dean C, Wu Q, Li J . Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron. 2011; 69(3):523-35. PMC: 4353647. DOI: 10.1016/j.neuron.2010.12.036. View

11.

Elmquist J, Elias C, Saper C . From lesions to leptin: hypothalamic control of food intake and body weight. Neuron. 1999; 22(2):221-32. DOI: 10.1016/s0896-6273(00)81084-3. View

12.

Butler A, Kesterson R, Khong K, Cullen M, Pelleymounter M, Dekoning J . A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology. 2000; 141(9):3518-21. DOI: 10.1210/endo.141.9.7791. View

13.

Roseberry A, Liu H, Jackson A, Cai X, Friedman J . Neuropeptide Y-mediated inhibition of proopiomelanocortin neurons in the arcuate nucleus shows enhanced desensitization in ob/ob mice. Neuron. 2004; 41(5):711-22. DOI: 10.1016/s0896-6273(04)00074-1. View

14.

Williams K, Margatho L, Lee C, Choi M, Lee S, Scott M . Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons. J Neurosci. 2010; 30(7):2472-9. PMC: 2836776. DOI: 10.1523/JNEUROSCI.3118-09.2010. View

15.

Cowley M, Smith R, Diano S, Tschop M, Pronchuk N, Grove K . The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003; 37(4):649-61. DOI: 10.1016/s0896-6273(03)00063-1. View

16.

Al-Qassab H, Smith M, Irvine E, Guillermet-Guibert J, Claret M, Choudhury A . Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab. 2009; 10(5):343-54. PMC: 2806524. DOI: 10.1016/j.cmet.2009.09.008. View

17.

Sohn J, Xu Y, Jones J, Wickman K, Williams K, Elmquist J . Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. Neuron. 2011; 71(3):488-97. PMC: 3184528. DOI: 10.1016/j.neuron.2011.06.012. View

18.

Balthasar N, Dalgaard L, Lee C, Yu J, Funahashi H, Williams T . Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005; 123(3):493-505. DOI: 10.1016/j.cell.2005.08.035. View

19.

Kushi A, Sasai H, Koizumi H, Takeda N, Yokoyama M, Nakamura M . Obesity and mild hyperinsulinemia found in neuropeptide Y-Y1 receptor-deficient mice. Proc Natl Acad Sci U S A. 1998; 95(26):15659-64. PMC: 28100. DOI: 10.1073/pnas.95.26.15659. View

20.

Shi Y, Lin S, Wong I, Baldock P, Aljanova A, Enriquez R . NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. PLoS One. 2010; 5(6):e11361. PMC: 2894044. DOI: 10.1371/journal.pone.0011361. View