Backstage of Eating Disorder-About the Biological Mechanisms Behind the Symptoms of Anorexia Nervosa

Overview

Journal Nutrients

Date 2020 Sep 2

PMID 32867089

Citations 14

Authors

Kamil Skowron

Magdalena Kurnik-Lucka

Emil Dadanski

Barbara Betkowska-Korpala

Krzysztof Gil

Affiliations

Soon will be listed here.

Abstract

Anorexia nervosa (AN) represents a disorder with the highest mortality rate among all psychiatric diseases, yet our understanding of its pathophysiological components continues to be fragmentary. This article reviews the current concepts regarding AN pathomechanisms that focus on the main biological aspects involving central and peripheral neurohormonal pathways, endocrine function, as well as the microbiome-gut-brain axis. It emerged from the unique complexity of constantly accumulating new discoveries, which hamper the ability to look at the disease in a more comprehensive way. The emphasis is placed on the mechanisms underlying the main symptoms and potential new directions that require further investigation in clinical settings.

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