Surveillance of Impact of PCV-10 Vaccine on Pneumococcal Meningitis in Mozambique, 2013 - 2015

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2017 Jun 13

PMID 28604773

Citations 13

Authors

Aquino Albino Nhantumbo

Goitom Weldegebriel

Reggis Katsande

Linda de Gouveia

Charlotte Elizabeth Come

Arlindo Zacarias Cuco

Vlademir Vicente Cantarelli

Cicero Dias

Juliana Caierao

Jason Mwenda Mathiu

Eduardo Samo Gudo

Affiliations

Soon will be listed here.

Abstract

Background: Vaccination using the 10-valent conjugate vaccine (PCV-10) was introduced into the Extended Program on Immunization in Mozambique in March 2013, however its impact on pediatric pneumococcal meningitis is unknown. In this study, we assessed for the first time the impact of PCV10 on the burden of pneumococcal meningitis in children less than 5 years of age at the three largest hospitals in Mozambique.

Method: Between March 2013 and December 2015, a total of 744 cerebrospinal fluid (CSF) samples were collected from eligible children, of which 160 (21.5%) were positive for S. pneumoniae. Of these, only 86 samples met the criteria for serotyping and were subsequently serotyped using sequential multiplex PCR (SM-PCR), but 17 samples were non-typable.

Results: The proportion of cases of pneumococcal meningitis decreased from 33.6% (124 of 369) in 2013 to 1.9% (3 of 160) in 2015 (p < 0.001). The relative frequency of PCV10 serotype cases also decreased from 84.2% (48 of 57) in 2013 to 0% (0 of 3) in 2015 (p = 0.006). Between 2013 and 2015, serotype coverage of PCV-10 and PCV13 vaccine formulations was 66.7% and 81.2%, respectively.

Conclusion: Altogether, our findings shows that introduction of PCV-10 immunization resulted in rapid decline of pneumococcal meningitis children less than 5 years old in Mozambique. This decline was accompanied by substantial changes in the pattern of circulating pneumococcal serotypes.

Citing Articles

Serotype distribution of invasive pneumococcal disease from countries of the WHO Africa, Americas, Eastern Mediterranean, South-East Asia, and Western Pacific regions: a systematic literature review from 2010 to 2021.

Fletcher M, Daigle D, Siapka M, Baay M, Hanquet G, Del Carmen Morales G Front Public Health. 2024; 12:1402795.

PMID: 39050608 PMC: 11266301. DOI: 10.3389/fpubh.2024.1402795.

Etiology of meningitis among adults in three quaternary hospitals in Mozambique, 2016-2017: The role of HIV.

Nhantumbo A, Come C, Maholela P, Munguambe A, da Costa P, Mott M PLoS One. 2022; 17(5):e0267949.

PMID: 35544535 PMC: 9094547. DOI: 10.1371/journal.pone.0267949.

Toward Establishing Integrated, Comprehensive, and Sustainable Meningitis Surveillance in Africa to Better Inform Vaccination Strategies.

Kwambana-Adams B, Cohen A, Hampton L, Nhantumbo A, Heyderman R, Antonio M J Infect Dis. 2021; 224(12 Suppl 2):S299-S306.

PMID: 34469559 PMC: 8409533. DOI: 10.1093/infdis/jiab268.

Decline in Vaccine-Type Streptococcus pneumoniae Serotypes Following Pneumococcal Conjugate Vaccine Introduction in Madagascar.

Raboba J, Rahajamanana V, Andriatahirintsoa E, Razafindrakoto A, Andrianarivelo A, Nimpa Mengouo M J Infect Dis. 2021; 224(12 Suppl 2):S285-S292.

PMID: 34469557 PMC: 8409527. DOI: 10.1093/infdis/jiab226.

The Burden of Invasive Bacterial Disease and the Impact of 10-Valent Pneumococcal Conjugate Vaccine in Children <5 years hospitalized for Meningitis in Lusaka, Zambia, 2010-2019.

Yamba K, Mpabalwani E, Nakazwe R, Mulendele E, Weldegebriel G, Mwenda J J Infect Dis. 2021; 224(12 Suppl 2):S275-S284.

PMID: 34469553 PMC: 8409534. DOI: 10.1093/infdis/jiab193.

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