Genetic Variants in Iranian Breast Cancer Patients

Overview

Journal Cell J

Specialty Cell Biology

Date 2017 Jun 6

PMID 28580310

Citations 19

Authors

Hamid Reza Khorshidi

Mohammad Taheri

Rezvan Noroozi

Shaghayegh Sarrafzadeh

Arezou Sayad

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

Objective: The genetic variants of the long non-coding RNA (an antisense noncoding RNA in the INK4 locus) as well as its expression have been shown to be associated with several human diseases including cancers. The aim of this study was to examine the association of variants with breast cancer susceptibility in Iranian patients.

Materials And Methods: In this case-control study, we genotyped rs1333045, rs4977574, rs1333048 and rs10757278 single nucleotide polymorphisms (SNPs) in 122 breast can- cer patients as well as in 200 normal age-matched subjects by tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR).

Results: The TT genotype at rs1333045 was significantly over-represented among pa- tients (P=0.038) but did not remain significant after multiple-testing correction. In addi- tion, among all observed haplotypes (with SNP order of rs1333045, rs1333048 rs4977574 and rs10757278), four haplotypes were shown to be associated with breast cancer risk. However, after multiple testing corrections, TCGA was the only haplotype which remained significant.

Conclusion: These results suggest that breast cancer risk is significantly associated with variants. Future work analyzing the expression of different associated haplotypes would further shed light on the role of in this disease.

Citing Articles

Association of lncRNA ANRIL rs10757278 A>G Variant, Tumor Size, Grading, Tumor Site, and Tumor Stage in Oral Squamous Cell Carcinoma Patients.

Salah M, Rezaee M, Fattahi M, Ghaderi A, Khademi B, Mokhtari M Rep Biochem Mol Biol. 2024; 13(1):59-66.

PMID: 39582818 PMC: 11580132. DOI: 10.61186/rbmb.13.1.59.

Allelic and Genotypic Analysis of LncRNA ANRIL rs4977574 A/G Mutations in Oral Squamous Cell Carcinoma Patients: Insights into Tumor Characteristics and Genotypic Correlations.

Amiri M, Amiri D, Mokhtari M, Lavaee F, Fattahi M, Ghaderi A Int J Dent. 2023; 2023:7738719.

PMID: 37829275 PMC: 10567505. DOI: 10.1155/2023/7738719.

Interactive effects of CDKN2B-AS1 gene polymorphism and habitual risk factors on oral cancer.

Yeh J, Chen Y, Chou Y, Su S, Chang L, Chen Y J Cell Mol Med. 2023; 27(21):3395-3403.

PMID: 37724356 PMC: 10623535. DOI: 10.1111/jcmm.17966.

Association between polymorphisms and risk of obsessive-compulsive disorder.

Akbari M, Hussen B, Eslami S, Neishabouri S, Ghafouri-Fard S Heliyon. 2023; 9(3):e14081.

PMID: 36923904 PMC: 10009448. DOI: 10.1016/j.heliyon.2023.e14081.

Association of Long Non-Coding RNAs (lncRNAs) and Polymorphism with Cervical Cancer.

Yao Y, Liang Y, Dong X, Liu S, Zhang S, Liu W Pharmgenomics Pers Med. 2022; 15:359-375.

PMID: 35480403 PMC: 9037735. DOI: 10.2147/PGPM.S358453.

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