Long Non-coding RNA ANRIL (CDKN2B-AS) is Induced by the ATM-E2F1 Signaling Pathway

Overview

Journal Cell Signal

Date 2013 Feb 19

PMID 23416462

Citations 104

Authors

Guohui Wan

Rohit Mathur

Xiaoxiao Hu

Yunhua Liu

Xinna Zhang

Guang Peng

Xiongbin Lu

Affiliations

Soon will be listed here.

Abstract

The maintenance of genome integrity is essential for the proper function and survival of all organisms. Human cells have evolved prompt and efficient DNA damage response to eliminate the detrimental effects of DNA lesions. The DNA damage response involves a complex network of processes that detect and repair DNA damage, in which long non-coding RNAs (lncRNAs), a new class of regulatory RNAs, may play important roles. Recent studies have identified a large number of lncRNAs in mammalian transcriptomes. However, little is known about the regulation and function of lncRNAs in the DNA damage response. In the present study, we demonstrate that one specific lncRNA, ANRIL, is transcriptionally up-regulated by the transcription factor E2F1 in an ATM-dependent manner following DNA damage, and elevated levels of ANRIL suppress the expression of INK4a, INK4b and ARF at the late-stage of DNA damage response, allowing the cell to return to normal at the completion of the DNA repair.

Citing Articles

NEAT1 modulates the TIRR/53BP1 complex to maintain genome integrity.

Kilgas S, Syed A, Toolan-Kerr P, Swift M, Roychoudhury S, Sarkar A Nat Commun. 2024; 15(1):8438.

PMID: 39349456 PMC: 11443056. DOI: 10.1038/s41467-024-52862-w.

The Potential Links between lncRNAs and Drug Tolerance in Lung Adenocarcinoma.

Davis W, Drummond C, Diermeier S, Reid G Genes (Basel). 2024; 15(7).

PMID: 39062685 PMC: 11276205. DOI: 10.3390/genes15070906.

The effects of ANRIL polymorphisms on colorectal cancer, tumor stage, and tumor grade among Iranian population.

Asadi-Tarani M, Darashti A, Javadi M, Rezaei M, Saravani M, Salimi S Mol Biol Rep. 2024; 51(1):486.

PMID: 38578390 DOI: 10.1007/s11033-024-09420-w.

The Role of Long Non-Coding RNAs in Cardiovascular Diseases.

Le L, Nhu C Int J Mol Sci. 2023; 24(18).

PMID: 37762106 PMC: 10531487. DOI: 10.3390/ijms241813805.

The Long Non-Coding RNA ANRIL in Cancers.

Sanchez A, Lhuillier J, Grosjean G, Ayadi L, Maenner S Cancers (Basel). 2023; 15(16).

PMID: 37627188 PMC: 10453084. DOI: 10.3390/cancers15164160.

References

Pasmant E, Laurendeau I, Heron D, Vidaud M, Vidaud D, Bieche I . Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res. 2007; 67(8):3963-9. DOI: 10.1158/0008-5472.CAN-06-2004. View

Guttman M, Rinn J . Modular regulatory principles of large non-coding RNAs. Nature. 2012; 482(7385):339-46. PMC: 4197003. DOI: 10.1038/nature10887. View

Bartek J, Lukas J . DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol. 2007; 19(2):238-45. DOI: 10.1016/j.ceb.2007.02.009. View

Lukas J, Lukas C, Bartek J . More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat Cell Biol. 2011; 13(10):1161-9. DOI: 10.1038/ncb2344. View

Kotake Y, Nakagawa T, Kitagawa K, Suzuki S, Liu N, Kitagawa M . Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene. 2010; 30(16):1956-62. PMC: 3230933. DOI: 10.1038/onc.2010.568. View

Han C, Wan G, Langley R, Zhang X, Lu X . Crosstalk between the DNA damage response pathway and microRNAs. Cell Mol Life Sci. 2012; 69(17):2895-906. PMC: 11115143. DOI: 10.1007/s00018-012-0959-8. View

Stacey S, Sulem P, Masson G, Gudjonsson S, Thorleifsson G, Jakobsdottir M . New common variants affecting susceptibility to basal cell carcinoma. Nat Genet. 2009; 41(8):909-14. PMC: 2973331. DOI: 10.1038/ng.412. View

Seiler D, Rouquette J, Schmid V, Strickfaden H, Ottmann C, Drexler G . Double-strand break-induced transcriptional silencing is associated with loss of tri-methylation at H3K4. Chromosome Res. 2011; 19(7):883-99. DOI: 10.1007/s10577-011-9244-1. View

Lu X, Ma O, Nguyen T, Jones S, Oren M, Donehower L . The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007; 12(4):342-54. DOI: 10.1016/j.ccr.2007.08.033. View

10.

Lin W, Lin F, Nevins J . Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 2001; 15(14):1833-44. PMC: 312742. View

11.

Wang K, Chang H . Molecular mechanisms of long noncoding RNAs. Mol Cell. 2011; 43(6):904-14. PMC: 3199020. DOI: 10.1016/j.molcel.2011.08.018. View

12.

Reinhardt H, Yaffe M . Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol. 2009; 21(2):245-55. PMC: 2699687. DOI: 10.1016/j.ceb.2009.01.018. View

13.

Yap K, Li S, Munoz-Cabello A, Raguz S, Zeng L, Mujtaba S . Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell. 2010; 38(5):662-74. PMC: 2886305. DOI: 10.1016/j.molcel.2010.03.021. View

14.

Clemson C, Hutchinson J, Sara S, Ensminger A, Fox A, Chess A . An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell. 2009; 33(6):717-26. PMC: 2696186. DOI: 10.1016/j.molcel.2009.01.026. View

15.

Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg A . Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature. 2008; 451(7175):202-6. PMC: 2743558. DOI: 10.1038/nature06468. View

16.

Wapinski O, Chang H . Long noncoding RNAs and human disease. Trends Cell Biol. 2011; 21(6):354-61. DOI: 10.1016/j.tcb.2011.04.001. View

17.

Sun Y, Jiang X, Chen S, Fernandes N, Price B . A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005; 102(37):13182-7. PMC: 1197271. DOI: 10.1073/pnas.0504211102. View

18.

Pasmant E, Sabbagh A, Vidaud M, Bieche I . ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS. FASEB J. 2010; 25(2):444-8. DOI: 10.1096/fj.10-172452. View

19.

Huarte M, Guttman M, Feldser D, Garber M, Koziol M, Kenzelmann-Broz D . A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010; 142(3):409-19. PMC: 2956184. DOI: 10.1016/j.cell.2010.06.040. View

20.

Zhang X, Wan G, Mlotshwa S, Vance V, Berger F, Chen H . Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res. 2010; 70(18):7176-86. PMC: 2940956. DOI: 10.1158/0008-5472.CAN-10-0697. View