Association Between Polymorphisms and Risk of Obsessive-compulsive Disorder

Overview

Journal Heliyon

Specialty Social Sciences

Date 2023 Mar 16

PMID 36923904

Authors

Mohammadarian Akbari

Bashdar Mahmud Hussen

Solat Eslami

Seyedeh Morvarid Neishabouri

Soudeh Ghafouri-Fard

Affiliations

Soon will be listed here.

Abstract

Obsessive-compulsive disorder (OCD) is a disorder in which genetic factors participate. ANRIL is an example of long non-coding RNAs with crucial roles in the pathoetiology of multifactorial disorders, including neuropsychiatric conditions. We appraised association between rs1333045, rs1333048, rs10757278 and rs4977574 polymorphisms and OCD in Iranian population. There were no remarkable differences in allele and genotype distribution of rs1333045, rs1333048, rs4977574, and rs10757278 between OCD Patients and normal controls. However, the CCGG haplotype (equivalent to rs1333045, rs1333048, rs4977574 and rs10757278, respectively) has been shown to decrease risk of OCD (OR (95% CI) = 0.57 (0.39-0.85), P value-0.006 and FDR q-value = 0.041). On the other hand, TCGA haplotype has been found as a risk haplotype for OCD (OR (95% CI) = 5.17 (1.44-18.55), P value = 0.005 and FDR q-value = 0.041). In brief, the current study indicates association between two ANRIL haplotypes and risk of OCD in Iranian people.

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References

Bolhuis K, McAdams T, Monzani B, Gregory A, Mataix-Cols D, Stringaris A . Aetiological overlap between obsessive-compulsive and depressive symptoms: a longitudinal twin study in adolescents and adults. Psychol Med. 2013; 44(7):1439-49. PMC: 3959155. DOI: 10.1017/S0033291713001591. View

Pauls D . The genetics of obsessive compulsive disorder: a review of the evidence. Am J Med Genet C Semin Med Genet. 2008; 148C(2):133-9. DOI: 10.1002/ajmg.c.30168. View

Liu D, Cao H, Kural K, Fang Q, Zhang F . Integrative analysis of shared genetic pathogenesis by autism spectrum disorder and obsessive-compulsive disorder. Biosci Rep. 2019; 39(12). PMC: 6928520. DOI: 10.1042/BSR20191942. View

Namvar A, Kahaei M, Fallah H, Nicknafs F, Ghafouri-Fard S, Taheri M . ANRIL Variants Are Associated with Risk of Neuropsychiatric Conditions. J Mol Neurosci. 2019; 70(2):212-218. DOI: 10.1007/s12031-019-01447-0. View

Karno M, Golding J, Sorenson S, Burnam M . The epidemiology of obsessive-compulsive disorder in five US communities. Arch Gen Psychiatry. 1988; 45(12):1094-9. DOI: 10.1001/archpsyc.1988.01800360042006. View

Pasmant E, Laurendeau I, Heron D, Vidaud M, Vidaud D, Bieche I . Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF. Cancer Res. 2007; 67(8):3963-9. DOI: 10.1158/0008-5472.CAN-06-2004. View

Kong Y, Hsieh C, Alonso L . : A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease. Front Endocrinol (Lausanne). 2018; 9:405. PMC: 6066557. DOI: 10.3389/fendo.2018.00405. View

Strom N, Soda T, Mathews C, Davis L . A dimensional perspective on the genetics of obsessive-compulsive disorder. Transl Psychiatry. 2021; 11(1):401. PMC: 8295308. DOI: 10.1038/s41398-021-01519-z. View

Pauls D . The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci. 2010; 12(2):149-63. PMC: 3181951. View

10.

Rusconi F, Battaglioli E, Venturin M . Psychiatric Disorders and lncRNAs: A Synaptic Match. Int J Mol Sci. 2020; 21(9). PMC: 7246907. DOI: 10.3390/ijms21093030. View

11.

Rezazadeh M, Gharesouran J, Moradi M, Noroozi R, Omrani M, Taheri M . Association Study of ANRIL Genetic Variants and Multiple Sclerosis. J Mol Neurosci. 2018; 65(1):54-59. DOI: 10.1007/s12031-018-1069-3. View

12.

Weissman M, Bland R, Canino G, Greenwald S, Hwu H, Lee C . The cross national epidemiology of obsessive compulsive disorder. The Cross National Collaborative Group. J Clin Psychiatry. 1994; 55 Suppl:5-10. View

13.

Stewart S, Yu D, Scharf J, Neale B, Fagerness J, Mathews C . Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry. 2012; 18(7):788-98. PMC: 4218751. DOI: 10.1038/mp.2012.85. View

14.

Mattheisen M, Samuels J, Wang Y, Greenberg B, Fyer A, McCracken J . Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry. 2014; 20(3):337-44. PMC: 4231023. DOI: 10.1038/mp.2014.43. View

15.

Khorshidi H, Taheri M, Noroozi R, Sarrafzadeh S, Sayad A, Ghafouri-Fard S . Genetic Variants in Iranian Breast Cancer Patients. Cell J. 2017; 19(Suppl 1):72-78. PMC: 5448323. DOI: 10.22074/cellj.2017.4496. View

16.

Safa A, Noroozi R, Taheri M, Ghafouri-Fard S . Association Analysis of ANRIL Polymorphisms and Haplotypes with Autism Spectrum Disorders. J Mol Neurosci. 2020; 71(1):187-192. DOI: 10.1007/s12031-020-01657-x. View

17.

Ortega-Alonso A, Ekelund J, Sarin A, Miettunen J, Veijola J, Jarvelin M . Genome-Wide Association Study of Psychosis Proneness in the Finnish Population. Schizophr Bull. 2017; 43(6):1304-1314. PMC: 5737890. DOI: 10.1093/schbul/sbx006. View

18.

Cipolla G, de Oliveira J, Salviano-Silva A, Lobo-Alves S, Lemos D, Oliveira L . Long Non-Coding RNAs in Multifactorial Diseases: Another Layer of Complexity. Noncoding RNA. 2018; 4(2). PMC: 6027498. DOI: 10.3390/ncrna4020013. View