Renal Association Clinical Practice Guideline in Post-operative Care in the Kidney Transplant Recipient
Overview
Affiliations
These guidelines cover the care of patients from the period following kidney transplantation until the transplant is no longer working or the patient dies. During the early phase prevention of acute rejection and infection are the priority. After around 3-6 months, the priorities change to preservation of transplant function and avoiding the long-term complications of immunosuppressive medication (the medication used to suppress the immune system to prevent rejection). The topics discussed include organization of outpatient follow up, immunosuppressive medication, treatment of acute and chronic rejection, and prevention of complications. The potential complications discussed include heart disease, infection, cancer, bone disease and blood disorders. There is also a section on contraception and reproductive issues.Immediately after the introduction there is a statement of all the recommendations. These recommendations are written in a language that we think should be understandable by many patients, relatives, carers and other interested people. Consequently we have not reworded or restated them in this lay summary. They are graded 1 or 2 depending on the strength of the recommendation by the authors, and AD depending on the quality of the evidence that the recommendation is based on.
Immune suppression sustained allograft acceptance requires PD1 inhibition of CD8+ T cells.
Miller-Handley H, Harper G, Pham G, Turner L, Shao T, Russi A J Immunol. 2025; 214(1):192-198.
PMID: 40073258 PMC: 11904129. DOI: 10.1093/jimmun/vkae007.
Late-Onset HSV-2 Encephalitis in a Kidney Transplant Recipient: A Rare Case Report.
Zjacic Puljiz D, Vrkic I, Jelicic I, Boric Skaro D, Delic Jukic I, Vicelic cutura L Life (Basel). 2025; 15(2).
PMID: 40003561 PMC: 11856058. DOI: 10.3390/life15020152.
Billany R, Macdonald J, Burns S, Chowdhury R, Ford E, Mubaarak Z PLoS One. 2025; 20(2):e0316031.
PMID: 39992959 PMC: 11849866. DOI: 10.1371/journal.pone.0316031.
Saleem N, Lim W, Stephens J, Wilson A, Bonevski B, Jaure A Transpl Int. 2025; 37:13965.
PMID: 39901917 PMC: 11788010. DOI: 10.3389/ti.2024.13965.
A Phase I Trial of the Pharmacokinetic Interaction Between Cannabidiol and Tacrolimus.
So G, Lu J, Koyama S, Cheng Y, Gisch D, McClara K Clin Pharmacol Ther. 2024; 117(3):716-723.
PMID: 39601108 PMC: 11835423. DOI: 10.1002/cpt.3504.