Nicholas Palmer
Overview
Explore the profile of Nicholas Palmer including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
208
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0
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Recent Articles
1.
Day J, Berdini V, Castro J, Chessari G, Davies T, Day P, et al.
J Med Chem
. 2024 Mar;
67(6):4655-4675.
PMID: 38462716
The ubiquitously expressed protein tyrosine phosphatase SHP2 is required for signaling downstream of receptor tyrosine kinases (RTKs) and plays a role in regulating many cellular processes. Genetic knockdown and pharmacological...
2.
Adiga A, Palmer N, Baek Y, Mortveit H, Ravi S
Front Big Data
. 2022 Feb;
5:796897.
PMID: 35198973
Globalization and climate change facilitate the spread and establishment of invasive species throughout the world via multiple pathways. These spread mechanisms can be effectively represented as diffusion processes on multi-scale,...
3.
Jacobs B, Palmer N, Shetty T, Dimaras H, Hajrasouliha A, Jusufbegovic D, et al.
Sci Rep
. 2021 Sep;
11(1):18996.
PMID: 34556761
Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs, with relatively low patient compliance and potential risks. Ongoing research explores alternative RVD treatments, including eye drops and...
4.
Heightman T, Berdini V, Bevan L, Buck I, Carr M, Courtin A, et al.
J Med Chem
. 2021 Aug;
64(16):12286-12303.
PMID: 34387469
Aberrant activation of the mitogen-activated protein kinase pathway frequently drives tumor growth, and the ERK1/2 kinases are positioned at a key node in this pathway, making them important targets for...
5.
Keane D, Glyde M, Dasgupta I, Gardiner C, Lindley E, Mitra S, et al.
BMC Nephrol
. 2021 May;
22(1):188.
PMID: 34016069
Background: Decisions around planned ultrafiltration volumes are the only part of the haemodialysis prescription decided upon at every session. Removing too much fluid or too little is associated with both...
6.
Palmer N, Maasch J, Torres M, de la Fuente-Nunez C
Infect Immun
. 2021 Feb;
89(4).
PMID: 33558318
Although antimicrobial resistance is an increasingly significant public health concern, there have only been two new classes of antibiotics approved for human use since the 1960s. Understanding the mechanisms of...
7.
Kack H, Doyle K, Hughes S, Bodnarchuk M, Lonn H, Van de Poel A, et al.
ACS Med Chem Lett
. 2019 Aug;
10(8):1222-1227.
PMID: 31413809
A series of pyrrolidine amino nitrile DPP1 inhibitors have been developed and characterized. The S2 pocket structure-activity relationship for these compounds shows significant gains in potency for DPP1 from interacting...
8.
Burg L, Palmer N, Kikhi K, Miroshnik E, Rueckert H, Gaddy E, et al.
PLoS Genet
. 2018 Nov;
14(11):e1007754.
PMID: 30427827
Many eukaryotic genes play essential roles in multiple biological processes in several different tissues. Conditional mutants are needed to analyze genes with such pleiotropic functions. In vertebrates, conditional gene inactivation...
9.
Baker R, Mark P, Patel R, Stevens K, Palmer N
BMC Nephrol
. 2017 Jun;
18(1):174.
PMID: 28571571
These guidelines cover the care of patients from the period following kidney transplantation until the transplant is no longer working or the patient dies. During the early phase prevention of...
10.
Khand A, Patel B, Palmer N, Jones J, Andron M, Perry R, et al.
Angiology
. 2015 Mar;
66(10):925-32.
PMID: 25759488
Aim: To conduct a systematic review and meta-analysis on retrograde wiring in chronic total occlusions (CTOs) with focus on its safety and feasibility. Methods And Results: We searched publications from...