IL-22BP Dictates Characteristics of Peyer's Patch Follicle-associated Epithelium for Antigen Uptake

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2017 May 18

PMID 28512157

Citations 34

Authors

Toshi Jinnohara

Takashi Kanaya

Koji Hase

Sayuri Sakakibara

Tamotsu Kato

Naoko Tachibana

Takaharu Sasaki

Yusuke Hashimoto

Toshiro Sato

Hiroshi Watarai

Jun Kunisawa

Naoko Shibata

Ifor R Williams

Hiroshi Kiyono

Hiroshi Ohno

Affiliations

Soon will be listed here.

Abstract

Interleukin-22 (IL-22) acts protectively and harmfully on intestinal tissue depending on the situation; therefore, IL-22 signaling needs to be tightly regulated. IL-22 binding protein (IL-22BP) binds IL-22 to inhibit IL-22 signaling. It is expressed in intestinal and lymphoid tissues, although its precise distribution and roles have remained unclear. In this study, we show that IL-22BP is highly expressed by CD11bCD8α dendritic cells in the subepithelial dome region of Peyer's patches (PPs). We found that IL-22BP blocks IL-22 signaling in the follicle-associated epithelium (FAE) covering PPs, indicating that IL-22BP plays a role in regulating the characteristics of the FAE. As expected, FAE of IL-22BP-deficient () mice exhibited altered properties such as the enhanced expression of mucus and antimicrobial proteins as well as prominent fucosylation, which are normally suppressed in FAE. Additionally, mice exhibited the decreased uptake of bacterial antigens into PPs without affecting M cell function. Our present study thus demonstrates that IL-22BP promotes bacterial uptake into PPs by influencing FAE gene expression and function.

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