Network Modelling of Gene Regulation

Overview

Journal Biophys Rev

Publisher Springer

Specialty Biophysics

Date 2017 May 17

PMID 28510232

Citations 2

Authors

Joshua W K Ho

Michael A Charleston

Affiliations

Soon will be listed here.

Abstract

Gene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology. The aim of the present article is to provide an overview of this rapidly expanding subject. In particular, we review some fundamental concepts of systems biology and discuss the role of network modelling in understanding complex biological systems. Several commonly used network modelling paradigms are surveyed with emphasis on their practical use in systems biology research.

Citing Articles

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Local difference measures between complex networks for dynamical system model evaluation.

Lange S, Donges J, Volkholz J, Kurths J PLoS One. 2015; 10(4):e0118088.

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