Strong Short-Range Cooperativity in Hydrogen-Bond Chains

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2017 May 12

PMID 28493462

Citations 14

Authors

Nicholas Dominelli-Whiteley

James J Brown

Kamila B Muchowska

Ioulia K Mati

Catherine Adam

Thomas A Hubbard

Alex Elmi

Alisdair J Brown

Ian A W Bell

Scott L Cockroft

Affiliations

Soon will be listed here.

Abstract

Chains of hydrogen bonds such as those found in water and proteins are often presumed to be more stable than the sum of the individual H bonds. However, the energetics of cooperativity are complicated by solvent effects and the dynamics of intermolecular interactions, meaning that information on cooperativity typically is derived from theory or indirect structural data. Herein, we present direct measurements of energetic cooperativity in an experimental system in which the geometry and the number of H bonds in a chain were systematically controlled. Strikingly, we found that adding a second H-bond donor to form a chain can almost double the strength of the terminal H bond, while further extensions have little effect. The experimental observations add weight to computations which have suggested that strong, but short-range cooperative effects may occur in H-bond chains.

Citing Articles

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