Chalcone: A Privileged Structure in Medicinal Chemistry

Overview

Journal Chem Rev

Publisher American Chemical Society

Specialty Chemistry

Date 2017 May 11

PMID 28488435

Citations 301

Authors

Chunlin Zhuang

Wen Zhang

Chunquan Sheng

Wannian Zhang

Chengguo Xing

Zhenyuan Miao

Affiliations

Soon will be listed here.

Abstract

Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.

Citing Articles

Determination of the Inhibitory Potential of Chalcones on Myeloperoxidase Enzyme Activity: In vitro and Molecular Docking Studies.

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PMID: 40080351 DOI: 10.1007/s12013-025-01719-0.

Synthesis, Characterization, and Docking Studies of Some New Chalcone Derivatives to Alleviate Skin Damage Due to UV Light.

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Microwave-Assisted Synthesis of Near-Infrared Chalcone Dyes: a Systematic Approach.

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Li Y, Huang R, Zhang W, Chen Q, Wang Q, Ye J Plants (Basel). 2025; 14(4).

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