Bis-Chalcones: Recent Reports of Their Diverse Applications in Biological and Material Sciences

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2024 Oct 21

PMID 39431097

Authors

Leena Siddiqui

Mohammed B Hawsawi

Ghayoor Abbas Chotana

Rahman Shah Zaib Saleem

Affiliations

Soon will be listed here.

Abstract

Originating from the basic chalcone structure, bis-chalcones are characterized by their dual ,-unsaturated carbonyl systems and carry a range of biological activities that include antimicrobial, antiviral, antiparasitic, antioxidant, antiproliferative, and chemical reactivities that warrant a review to cover recent progress. Thus, this review presents the significant potential demonstrated by bis-chalcones in various biological applications. For example, compounds showed excellent antiparasitic activity against leishmania with good selectivity index, and compounds - showed submicromolar activity against SupT1 cells. Compound stood out in its antiproliferative activity against a panel of 60 different cell lines. Compounds and have been shown as submicromolar noncompetitive xanthine oxidase inhibitors. We also present their recent applications in material science, for example, as photosensitizers and photoinitiators, to showcase their broader potential for innovation in both medicinal chemistry and industrial applications.

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