Molecular Hybridization: a Useful Tool in the Design of New Drug Prototypes

Overview

Journal Curr Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2007 Jul 14

PMID 17627520

Citations 202

Authors

Claudio Viegas-Junior

Amanda Danuello

Vanderlan da Silva Bolzani

Eliezer J Barreiro

Carlos Alberto Manssour Fraga

Affiliations

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Abstract

Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties.

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