Vitamin D Deficiency and Interleukin-17 Relationship in Severe Obstructive Sleep Apnea-hypopnea Syndrome

Overview

Journal Ann Thorac Med

Specialty Pulmonary Medicine

Date 2017 May 5

PMID 28469721

Citations 15

Authors

Sonia Toujani

Wajih Kaabachi

Meriem Mjid

Kamel Hamzaoui

Jouda Cherif

Majed Beji

Affiliations

Soon will be listed here.

Abstract

Purpose: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea-hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17).

Methods: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected. The serum levels of VD and IL-17 were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively.

Results: Ninety-two severe OSAHS patients and thirty controls were enrolled in the study. All OSAHS patients had VD deficiency. The mean level of VD was at 7.9 ng/ml among OSAHS group versus 16.8 ng/ml among control group. IL-17A levels were elevated (20.3 pg/ml) in OSAHS group compared to healthy group (10.05 pg/ml). VD levels were negatively correlated with nocturia severity ( = -0.26; = 0.01) and positively correlated with mean O saturation ( = 0.59; = 0.02) and lowest O saturation ( = 0.3; = 0.03). IL-17 levels were positively correlated with nocturia severity ( = 0.24; = 0.03) and negatively correlated with mean O saturation ( = -0.42; = 0.03). A significant negative association was observed between IL-7 and VD levels ( = -0.64, = 0.2 10). The magnitude of this correlation was higher for important nocturia, lower MSaO, or higher BMI.

Conclusions: VD deficiency in patients with severe OSAHS is common with a negative association between IL-17 and VD serum levels. Hypoxia could play an important role in this association. Further studies are needed to clarify this relationship.

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References

Mete T, Yalcin Y, Berker D, Ciftci B, Guven S, Topaloglu O . Obstructive sleep apnea syndrome and its association with vitamin D deficiency. J Endocrinol Invest. 2013; 36(9):681-5. DOI: 10.3275/8923. View

Lin Q, Chen L, Yu Y, Liu K, Gao S . Obstructive sleep apnea syndrome is associated with metabolic syndrome and inflammation. Eur Arch Otorhinolaryngol. 2013; 271(4):825-31. DOI: 10.1007/s00405-013-2669-8. View

Goswami U, Ensrud K, Paudel M, Redline S, Schernhammer E, Shikany J . Vitamin D Concentrations and Obstructive Sleep Apnea in a Multicenter Cohort of Older Males. Ann Am Thorac Soc. 2016; 13(5):712-8. PMC: 5018890. DOI: 10.1513/AnnalsATS.201507-440OC. View

Barcelo A, Esquinas C, Pierola J, de la Pena M, Sanchez-de-la-Torre M, Montserrat J . Vitamin D status and parathyroid hormone levels in patients with obstructive sleep apnea. Respiration. 2012; 86(4):295-301. DOI: 10.1159/000342748. View

Carpagnano G, Kharitonov S, Resta O, Foschino-Barbaro M, Gramiccioni E, Barnes P . Increased 8-isoprostane and interleukin-6 in breath condensate of obstructive sleep apnea patients. Chest. 2002; 122(4):1162-7. DOI: 10.1378/chest.122.4.1162. View

Mousa A, Misso M, Teede H, Scragg R, de Courten B . Effect of vitamin D supplementation on inflammation: protocol for a systematic review. BMJ Open. 2016; 6(4):e010804. PMC: 4823456. DOI: 10.1136/bmjopen-2015-010804. View

Nadeem R, Molnar J, Madbouly E, Nida M, Aggarwal S, Sajid H . Serum inflammatory markers in obstructive sleep apnea: a meta-analysis. J Clin Sleep Med. 2013; 9(10):1003-12. PMC: 3778171. DOI: 10.5664/jcsm.3070. View

Ying L, Li H, Pan Z, Ma S, Zhang P, Wang Q . Relationship of redundant Th17 cells and IL-17A, but not IL-17 F, with the severity of obstructive sleep apnoea/hypopnoea syndrome (OSAHS). BMC Pulm Med. 2014; 14:84. PMC: 4026153. DOI: 10.1186/1471-2466-14-84. View

Guven S, Turkkani M, Ciftci B, Ulukavak Ciftci T, Erdogan Y . The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea. Sleep Breath. 2011; 16(1):217-21. DOI: 10.1007/s11325-011-0492-2. View

10.

Johns M . A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991; 14(6):540-5. DOI: 10.1093/sleep/14.6.540. View

11.

Korkmaz M, Korkmaz H, Kucuker F, Ayyildiz S, Cankaya S . Evaluation of the association of sleep apnea-related systemic inflammation with CRP, ESR, and neutrophil-to-lymphocyte ratio. Med Sci Monit. 2015; 21:477-81. PMC: 4335587. DOI: 10.12659/MSM.893175. View

12.

Tam C, Wong M, Tam K, Aouad L, Waters K . The effect of acute intermittent hypercapnic hypoxia treatment on IL-6, TNF-alpha, and CRP levels in piglets. Sleep. 2007; 30(6):723-7. PMC: 1978356. DOI: 10.1093/sleep/30.6.723. View

13.

Erden E, Genc S, Motor S, Ustun I, Ulutas K, Bilgic H . Investigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndrome. Endocrine. 2013; 45(2):311-8. DOI: 10.1007/s12020-013-0022-z. View

14.

Wu K, Su X, Li G, Zhang N . Antioxidant Carbocysteine Treatment in Obstructive Sleep Apnea Syndrome: A Randomized Clinical Trial. PLoS One. 2016; 11(2):e0148519. PMC: 4743936. DOI: 10.1371/journal.pone.0148519. View

15.

Kaynak H, Kaynak D, Oztura I . Does frequency of nocturnal urination reflect the severity of sleep-disordered breathing?. J Sleep Res. 2004; 13(2):173-6. DOI: 10.1111/j.1365-2869.2004.00400.x. View

16.

Ahmad Y, Sharma N, Garg I, Ahmad M, Sharma M, Bhargava K . An insight into the changes in human plasma proteome on adaptation to hypobaric hypoxia. PLoS One. 2013; 8(7):e67548. PMC: 3699623. DOI: 10.1371/journal.pone.0067548. View

17.

Roytblat L, Rachinsky M, Fisher A, Greemberg L, Shapira Y, Douvdevani A . Raised interleukin-6 levels in obese patients. Obes Res. 2001; 8(9):673-5. DOI: 10.1038/oby.2000.86. View

18.

Bischoff H, Stahelin H, Urscheler N, Ehrsam R, Vonthein R, Tyndall A . Muscle strength in the elderly: its relation to vitamin D metabolites. Arch Phys Med Rehabil. 1999; 80(1):54-8. DOI: 10.1016/s0003-9993(99)90307-6. View

19.

Villa M, Ianniello F, Tocci G, Evangelisti M, Miano S, Ferrucci A . Early cardiac abnormalities and increased C-reactive protein levels in a cohort of children with sleep disordered breathing. Sleep Breath. 2011; 16(1):101-10. DOI: 10.1007/s11325-010-0462-0. View

20.

Chinellato I, Piazza M, Sandri M, Peroni D, Cardinale F, Piacentini G . Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma. Eur Respir J. 2010; 37(6):1366-70. DOI: 10.1183/09031936.00044710. View