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Obstructive Sleep Apnea and Vitamin D Level: Has the Dust Settled?

Overview
Journal Clin Respir J
Specialty Pulmonary Medicine
Date 2023 Feb 6
PMID 36746181
Authors
Affiliations
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Abstract

Obstructive sleep apnea and vitamin D deficiency are associated with multiple complications with increased morbidity and mortality. However, the relationship between these two entities remains unclear, with clinical studies demonstrating contradictory results. This narrative review aims to present the current evidence and understanding of this relationship and discuss the possible mechanisms linking these two disease entities. Finally, we summarize and propose areas of opportunity for future research.

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References
1.
Gonzalez E, Sachdeva A, Oliver D, Martin K . Vitamin D insufficiency and deficiency in chronic kidney disease. A single center observational study. Am J Nephrol. 2004; 24(5):503-10. DOI: 10.1159/000081023. View

2.
Dix C, Barcley J, Wright O . The role of vitamin D in adipogenesis. Nutr Rev. 2017; 76(1):47-59. DOI: 10.1093/nutrit/nux056. View

3.
Reis J, von Muhlen D, Miller 3rd E . Relation of 25-hydroxyvitamin D and parathyroid hormone levels with metabolic syndrome among US adults. Eur J Endocrinol. 2008; 159(1):41-8. DOI: 10.1530/EJE-08-0072. View

4.
Loh H, Lim Q, Chai C, Goh S, Lim L, Yee A . Influence and implications of the renin-angiotensin-aldosterone system in obstructive sleep apnea: An updated systematic review and meta-analysis. J Sleep Res. 2022; 32(1):e13726. PMC: 10078316. DOI: 10.1111/jsr.13726. View

5.
Matsunuma A, Horiuchi N . Leptin attenuates gene expression for renal 25-hydroxyvitamin D3-1alpha-hydroxylase in mice via the long form of the leptin receptor. Arch Biochem Biophys. 2007; 463(1):118-27. DOI: 10.1016/j.abb.2007.02.031. View