The Association Between Serum Vitamin D and Obstructive Sleep Apnea: an Updated Meta-analysis

Overview

Journal Respir Res

Specialty Pulmonary Medicine

Date 2020 Nov 10

PMID 33167989

Citations 13

Authors

Xiaoyan Li

Jie He

Jie Yun

Affiliations

Soon will be listed here.

Abstract

Background: The objective was to determine whether OSA patients have a low serum vitamin D level by systematic review and meta-analysis.

Methods: This study searched the following electronic bibliographic databases: Embase, Medline, Web of Science, PubMed, VIP, Wanfang, CNKI and SinoMed. All data were searched between January 2000 and August 2020. The quality of the included studies was estimated by two researchers according to the Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality. All qualified studies and statistical analyses were conducted using RevMan 5.2.

Results: Twenty-nine eligible studies compromising 6717 participants met the inclusion criteria of the meta-analysis. The results revealed that the serum 25(OH)D level was significantly lower in OSA patients than the controls. According to the severity of the disease, subgroup analysis was performed; the results demonstrated that the serum 25(OH)D level was not decreased in mild OSA patients compared with the controls, while the serum 25(OH)D level in moderate and severe OSA patients was lower than that in the controls. Furthermore, based on ethnicity, BMI, PSG type, study quality and latitude, the subjects were divided into different subgroups for meta-analysis. The results revealed that the serum 25(OH)D level in all OSA subgroups was decreased compared with that in the control group.

Conclusions: The present meta-analysis shows that the serum vitamin D level was different between OSA patients and healthy people. OSA patients could have a low serum vitamin D level.

Citing Articles

Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis.

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The role of interaction between vitamin D and VDR FokI gene polymorphism (rs2228570) in sleep quality of adults.

de Menezes-Junior L, Sabiao T, de Moura S, Batista A, de Menezes M, Carraro J Sci Rep. 2024; 14(1):8141.

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Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea.

Kechribari I, Kontogianni M, Georgoulis M, Lamprou K, Perraki E, Vagiakis E Life (Basel). 2024; 14(2).

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Annamalai R, Sujhithra A, Danis Vijay D J Clin Orthop Trauma. 2023; 46:102278.

PMID: 38059053 PMC: 10696121. DOI: 10.1016/j.jcot.2023.102278.

Relationship of serum 25-hydroxyvitamin D, obesity with new-onset obstructive sleep apnea.

Zhang Y, Zhang Y, Ye Z, Zhou C, Yang S, Liu M Int J Obes (Lond). 2023; 48(2):218-223.

PMID: 37891401 DOI: 10.1038/s41366-023-01402-5.

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