MiR-23b Controls ALDH1A1 Expression in Cervical Cancer Stem Cells

Overview

Journal BMC Cancer

Publisher Biomed Central

Specialty Oncology

Date 2017 Apr 29

PMID 28449663

Citations 24

Authors

Weiwen Wang

Yang Li

Na Liu

Yu Gao

Long Li

Affiliations

Soon will be listed here.

Abstract

Background: Cancer stem cells has been widely investigated due to its essential role in cancer progression and drug resistance. Here, we try to find a new therapeutic target for cervical cancer stem cells.

Methods: We detected ALDH1A1-associated miRNAs expression in our isolated tumorspheres and their corresponding parental cells. Sphere formation assay was also used to determine stemness after cells were manipulated with miR-23b plasmid or miR-23b inhibitor.

Results: We found that miR-23b was under-expressed in cervical cancer stem cells to maintain high levels of ALDH1A1. Introduction of miR-23b into cervical cancer cells could alter stemness and cisplatin sensitivity.

Conclusions: miR-23b plays key role in maintaining stemness of cervical cancer stem cells and can be developed as therapeutic target to better fight against cervical cancer.

Citing Articles

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ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism.

Yue H, Hu Z, Hu R, Guo Z, Zheng Y, Wang Y Front Oncol. 2022; 12:918778.

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