Cancer Stem Cells: an Evolving Concept

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2012 Jan 13

PMID 22237392

Citations 603

Authors

Long V Nguyen

Robert Vanner

Peter Dirks

Connie J Eaves

Affiliations

Soon will be listed here.

Abstract

The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. This idea is not new, but has recently gained prominence because of advances in defining normal tissue hierarchies, a greater appreciation of the multistep nature of oncogenesis and improved methods to propagate primary human cancers in immunodeficient mice. As a result we have obtained new insights into why the CSC concept is not universally applicable, as well as a new basis for understanding the complex evolution, phenotypic heterogeneity and therapeutic challenges of many human cancers.

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References

Stephenson J, AXELRAD A, McLeod D, Shreeve M . Induction of colonies of hemoglobin-synthesizing cells by erythropoietin in vitro. Proc Natl Acad Sci U S A. 1971; 68(7):1542-6. PMC: 389236. DOI: 10.1073/pnas.68.7.1542. View

Jung P, Sato T, Merlos-Suarez A, Barriga F, Iglesias M, Rossell D . Isolation and in vitro expansion of human colonic stem cells. Nat Med. 2011; 17(10):1225-7. DOI: 10.1038/nm.2470. View

Kamel-Reid S, Letarte M, Sirard C, Doedens M, Grunberger T, Fulop G . A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science. 1989; 246(4937):1597-600. DOI: 10.1126/science.2595371. View

Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H . Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mice. Gastroenterology. 2009; 137(3):1114-26, 1126.e1-14. DOI: 10.1053/j.gastro.2009.06.001. View

Stich H, Emson H . Aneuploid deoxyribonucleic acid content of human carcinomas. Nature. 1959; 184(Suppl 5):290-1. DOI: 10.1038/184290a0. View

Spangrude G, Heimfeld S, Weissman I . Purification and characterization of mouse hematopoietic stem cells. Science. 1988; 241(4861):58-62. DOI: 10.1126/science.2898810. View

Cotsarelis G, Cheng S, Dong G, Sun T, Lavker R . Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell. 1989; 57(2):201-9. DOI: 10.1016/0092-8674(89)90958-6. View

Cortes J, OBrien S, Kantarjian H . Discontinuation of imatinib therapy after achieving a molecular response. Blood. 2004; 104(7):2204-5. DOI: 10.1182/blood-2004-04-1335. View

Taussig D, Miraki-Moud F, Anjos-Afonso F, Pearce D, Allen K, Ridler C . Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells. Blood. 2008; 112(3):568-75. DOI: 10.1182/blood-2007-10-118331. View

10.

Koschmieder S, Gottgens B, Zhang P, Iwasaki-Arai J, Akashi K, Kutok J . Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL leukemogenesis. Blood. 2004; 105(1):324-34. DOI: 10.1182/blood-2003-12-4369. View

11.

Quintana E, Shackleton M, Sabel M, Fullen D, Johnson T, Morrison S . Efficient tumour formation by single human melanoma cells. Nature. 2008; 456(7222):593-8. PMC: 2597380. DOI: 10.1038/nature07567. View

12.

Pierce Jr G, DIXON Jr F, VERNEY E . Teratocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies. Lab Invest. 1960; 9:583-602. View

13.

Wunderlich M, Chou F, Link K, Mizukawa B, Perry R, Carroll M . AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3. Leukemia. 2010; 24(10):1785-8. PMC: 5439963. DOI: 10.1038/leu.2010.158. View

14.

Paran M, Sachs L, Barak Y, Resnitzky P . In vitro induction of granulocyte differentiation in hematopoietic cells from leukemic and non-leukemic patients. Proc Natl Acad Sci U S A. 1970; 67(3):1542-9. PMC: 283388. DOI: 10.1073/pnas.67.3.1542. View

15.

Hamburger A, Salmon S . Primary bioassay of human tumor stem cells. Science. 1977; 197(4302):461-3. DOI: 10.1126/science.560061. View

16.

Kim C . Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells. Am J Physiol Lung Cell Mol Physiol. 2007; 293(5):L1092-8. DOI: 10.1152/ajplung.00015.2007. View

17.

Lepper C, Conway S, Fan C . Adult satellite cells and embryonic muscle progenitors have distinct genetic requirements. Nature. 2009; 460(7255):627-31. PMC: 2767162. DOI: 10.1038/nature08209. View

18.

Ishizawa K, Rasheed Z, Karisch R, Wang Q, Kowalski J, Susky E . Tumor-initiating cells are rare in many human tumors. Cell Stem Cell. 2010; 7(3):279-82. PMC: 2945729. DOI: 10.1016/j.stem.2010.08.009. View

19.

Fulop G, Phillips R . The scid mutation in mice causes a general defect in DNA repair. Nature. 1990; 347(6292):479-82. DOI: 10.1038/347479a0. View

20.

Schultz E, McCormick K . Skeletal muscle satellite cells. Rev Physiol Biochem Pharmacol. 1994; 123:213-57. DOI: 10.1007/BFb0030904. View