ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Jul 11

PMID 35814382

Authors

Hanxun Yue

Zenan Hu

Rui Hu

Zeying Guo

Ya Zheng

Yuping Wang

Yongning Zhou

Affiliations

Soon will be listed here.

Abstract

Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers the maintenance of cancer stem cell properties, modification of metabolism, promotion of DNA repair. ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully understood. This review will provide insight into the status of ALDH1A1 research and new viewpoint for cancer therapy.

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