Atrial Natriuretic Factor Inhibits Vasopressin-stimulated Osmotic Water Permeability in Rat Inner Medullary Collecting Duct

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1988 Oct 1

PMID 2844855

Citations 25

Authors

H Nonoguchi

J M Sands

M A Knepper

Affiliations

Soon will be listed here.

Abstract

The inner medullary collecting duct (IMCD) has been proposed to be a site of atrial natriuretic factor (ANF) action. We carried out experiments in isolated perfused terminal IMCDs to determine whether ANF (rat ANF 1-28) affects either osmotic water permeability (Pf) or urea permeability. In the presence of a submaximally stimulating concentration of vasopressin (10(-11) M), ANF (100 nM) significantly reduced Pf by an average of 46%. Lower concentrations of ANF also significantly inhibited vasopressin-stimulated Pf by the following percentages: 0.01 nM ANF, 18%; 0.1 nM, 46%; 1 nM, 48%. Addition of exogenous cyclic GMP (0.1 mM) mimicked the effect of ANF, decreasing Pf by an average of 48%. ANF also inhibited cyclic AMP-stimulated Pf by an average of 31%. ANF did not affect urea permeability, nor did it alter vasopressin-stimulated cyclic AMP accumulation. We conclude that ANF at physiological concentrations causes a large inhibition of vasopressin-stimulated Pf in the rat terminal IMCD, and that cyclic GMP is the second messenger mediating the effect. ANF appears to act at a site distal to cyclic AMP generation in the chain of events linking vasopressin receptor binding to an increase in osmotic water permeability.

Citing Articles

Particulate Guanylyl Cyclase A/cGMP Signaling Pathway in the Kidney: Physiologic and Therapeutic Indications.

Chen Y, Burnett J Int J Mol Sci. 2018; 19(4).

PMID: 29584705 PMC: 5979439. DOI: 10.3390/ijms19041006.

Do we need to know more about the effects of hormones on lower urinary tract dysfunction? ICI-RS 2014.

Hanna-Mitchell A, Robinson D, Cardozo L, Everaert K, Petkov G Neurourol Urodyn. 2016; 35(2):299-303.

PMID: 26872571 PMC: 6103166. DOI: 10.1002/nau.22809.

Effects of atrial natriuretic peptide on bicarbonate transport in long- and short-looped medullary thick ascending limbs of rats.

Nonoguchi H, Izumi Y, Nakayama Y, Matsuzaki T, Yasuoka Y, Inoue T PLoS One. 2013; 8(12):e83146.

PMID: 24376658 PMC: 3871552. DOI: 10.1371/journal.pone.0083146.

The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus.

Cipriani P, Kim S, Klein J, Sim J, von Bergen T, Blount M Front Physiol. 2012; 3:176.

PMID: 22685437 PMC: 3368392. DOI: 10.3389/fphys.2012.00176.

Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases.

Polzin D, Kaminski H, Kastner C, Wang W, Kramer S, Gambaryan S Kidney Int. 2010; 78(7):650-9.

PMID: 20613715 PMC: 4433746. DOI: 10.1038/ki.2010.197.

References

Morgan T, BERLINER R . Permeability of the loop of Henle, vasa recta, and collecting duct to water, urea, and sodium. Am J Physiol. 1968; 215(1):108-15. DOI: 10.1152/ajplegacy.1968.215.1.108. View

Sands J, Nonoguchi H, Knepper M . Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments. Am J Physiol. 1987; 253(5 Pt 2):F823-32. DOI: 10.1152/ajprenal.1987.253.5.F823. View

DUNN F, Brennan T, Nelson A, Robertson G . The role of blood osmolality and volume in regulating vasopressin secretion in the rat. J Clin Invest. 1973; 52(12):3212-9. PMC: 302597. DOI: 10.1172/JCI107521. View

Schafer J, Troutman S, Andreoli T . Effect of antidiuretic hormone on water and solute permeation, and the activation energies for these processes, in mammalian cortical collecting tubules: evidence for parallel ADH-sensitive pathways for water and solute diffusion in luminal plasma.... J Membr Biol. 1977; 31(1-2):103-29. DOI: 10.1007/BF01869401. View

Ballermann B . A highly sensitive radioreceptor assay for atrial natriuretic peptide in rat plasma. Am J Physiol. 1988; 254(1 Pt 2):F159-63. DOI: 10.1152/ajprenal.1988.254.1.F159. View

van de Stolpe A, Jamison R . Micropuncture study of the effect of ANP on the papillary collecting duct in the rat. Am J Physiol. 1988; 254(4 Pt 2):F477-83. DOI: 10.1152/ajprenal.1988.254.4.F477. View

Star R, Nonoguchi H, Balaban R, Knepper M . Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest. 1988; 81(6):1879-88. PMC: 442639. DOI: 10.1172/JCI113534. View

Gunning M, Ballermann B, Silva P, Brenner B, Zeidel M . Characterization of ANP receptors in rabbit inner medullary collecting duct cells. Am J Physiol. 1988; 255(2 Pt 2):F324-30. DOI: 10.1152/ajprenal.1988.255.2.F324. View

Moss J, Manganiello V, Vaughan M . Substrate and effector specificity of a guanosine 3':5'-monophosphate phosphodiesterase from rat liver. J Biol Chem. 1977; 252(15):5211-5. View

10.

de Bold A, Borenstein H, Veress A, Sonnenberg H . A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981; 28(1):89-94. DOI: 10.1016/0024-3205(81)90370-2. View

11.

Sonnenberg H, Cupples W, de Bold A, Veress A . Intrarenal localization of the natriuretic effect of cardiac atrial extract. Can J Physiol Pharmacol. 1982; 60(9):1149-52. DOI: 10.1139/y82-166. View

12.

Rocha A, Kudo L . Water, urea, sodium, chloride, and potassium transport in the in vitro isolated perfused papillary collecting duct. Kidney Int. 1982; 22(5):485-91. DOI: 10.1038/ki.1982.201. View

13.

Briggs J, Steipe B, Schubert G, Schnermann J . Micropuncture studies of the renal effects of atrial natriuretic substance. Pflugers Arch. 1982; 395(4):271-6. DOI: 10.1007/BF00580789. View

14.

Camargo M, Kleinert H, Atlas S, SEALEY J, LARAGH J, Maack T . Ca-dependent hemodynamic and natriuretic effects of atrial extract in isolated rat kidney. Am J Physiol. 1984; 246(4 Pt 2):F447-56. DOI: 10.1152/ajprenal.1984.246.4.F447. View

15.

Winquist R, Faison E, Waldman S, Schwartz K, Murad F, Rapoport R . Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle. Proc Natl Acad Sci U S A. 1984; 81(23):7661-4. PMC: 392208. DOI: 10.1073/pnas.81.23.7661. View

16.

Tremblay J, Gerzer R, Vinay P, Pang S, Beliveau R, Hamet P . The increase of cGMP by atrial natriuretic factor correlates with the distribution of particulate guanylate cyclase. FEBS Lett. 1985; 181(1):17-22. DOI: 10.1016/0014-5793(85)81105-4. View

17.

Lang R, Tholken H, Ganten D, Luft F, Ruskoaho H, Unger T . Atrial natriuretic factor--a circulating hormone stimulated by volume loading. Nature. 1985; 314(6008):264-6. DOI: 10.1038/314264a0. View

18.

NEEDLEMAN P, Adams S, Cole B, Currie M, GELLER D, Michener M . Atriopeptins as cardiac hormones. Hypertension. 1985; 7(4):469-82. DOI: 10.1161/01.hyp.7.4.469. View

19.

Maack T, Camargo M, Kleinert H, LARAGH J, Atlas S . Atrial natriuretic factor: structure and functional properties. Kidney Int. 1985; 27(4):607-15. DOI: 10.1038/ki.1985.54. View

20.

Murray R, Itoh S, Inagami T, Misono K, Seto S, Scicli A . Effects of synthetic atrial natriuretic factor in the isolated perfused rat kidney. Am J Physiol. 1985; 249(4 Pt 2):F603-9. DOI: 10.1152/ajprenal.1985.249.4.F603. View