The Long Non-coding RNA NONHSAG026900 Predicts Prognosis As a Favorable Biomarker in Patients with Diffuse Large B-cell Lymphoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Apr 21

PMID 28423735

Citations 14

Authors

Shuangtao Zhao

Shuangsang Fang

Yanhua Liu

Xixi Li

Shengyou Liao

Jinwen Chen

Jingjia Liu

Lianhe Zhao

Hui Li

Wei Zhou

Wenzhi Shen

Xiaoli Dong

Rong Xiang

Luhua Wang

Yi Zhao

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs are known to be involved in cancer progression, but their biological functions and prognostic values are still largely unexplored in diffuse large B-cell lymphoma. In this study, long non-coding RNAs expression was characterized in 1,403 samples including normal and diffuse large B-cell lymphoma by repurposing 7 microarray datasets. Compared with any stage of normal B cells, NONHSAG026900 expression was significantly decreased in tumor samples. And in germinal center B-cell subtype, the significantly higher expression of NONHSAG026900 indicated it was a favorable prognosis biomarker. Then the prognostic power of NONHSAG026900 was validated with another independent dataset and NONHSAG026900 improved the predictive power of International Prognostic Index as an independent factor. Moreover, functional prediction and validation demonstrated that NONHSAG026900 could inhibit cell cycle activity to restrain tumor proliferation. These findings identified NONHSAG026900 as a novel prognostic biomarker and offered a new therapeutic target for diffuse large B-cell lymphoma patients.

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