MicroRNA and Other Non-Coding RNAs in Epstein-Barr Virus-Associated Cancers

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Aug 7

PMID 34359809

Citations 20

Authors

Kin Israel Notarte

Suranga Senanayake

Imee Macaranas

Pia Marie Albano

Lucia Mundo

Eanna Fennell

Lorenzo Leoncini

Paul Murray

Affiliations

Soon will be listed here.

Abstract

EBV is a direct causative agent in around 1.5% of all cancers. The oncogenic properties of EBV are related to its ability to activate processes needed for cellular proliferation, survival, migration, and immune evasion. The EBV latency program is required for the immortalization of infected B cells and involves the expression of non-coding RNAs (ncRNAs), including viral microRNAs. These ncRNAs have different functions that contribute to virus persistence in the asymptomatic host and to the development of EBV-associated cancers. In this review, we discuss the function and potential clinical utility of EBV microRNAs and other ncRNAs in EBV-associated malignancies. This review is not intended to be comprehensive, but rather to provide examples of the importance of ncRNAs.

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