Elevated Progesterone and Its Impact on Birth Weight After Fresh Embryo Transfers

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2017 Apr 19

PMID 28417348

Citations 11

Authors

Yetunde Ibrahim

Miriam J Haviland

Michele R Hacker

Alan S Penzias

Kim L Thornton

Denny Sakkas

Affiliations

Soon will be listed here.

Abstract

Purpose: The purpose of the study was to examine the association between serum progesterone levels on the day of hCG administration and birth weight among singleton live births after fresh embryo transfer.

Methods: This study was conducted as a retrospective cohort database analysis on patients who underwent IVF treatment cycles from January 2004 to April 2012. The study was performed at a University affiliated private infertility practice. All cycles that had achieved a singleton live birth after fresh embryo transfer and for which progesterone was measured on the day of hCG administration were examined. Generalized linear models were used to calculate mean birth weight and z-scores.

Results: We analyzed 817 fresh IVF embryo transfers in which birth weight, gestational age, and progesterone (ng/mL) level on day of hCG administration were documented. While there was a decrease in birth weight as progesterone quartile [≤0.54; >0.54 to ≤0.81; >0.81 to ≤1.17; >1.17 ng/mL] increased, the difference in mean birth weights among the four quartiles was not statistically significant (p = 0.11) after adjusting for maternal age and peak estradiol levels. When dichotomizing based on a serum progesterone considered clinically elevated, cycles with progesterone >2.0 ng/mL had a significantly lower mean singleton birth weight (2860 g (95% CI 2642 g, 3079 g)) compared to cycles with progesterone ≤2.0 ng/mL (3167 g (95% CI 3122 g, 3211 g) p = 0.007)) after adjusting for maternal age and estradiol.

Conclusion: We demonstrated that caution should be exercised when performing fresh embryo transfers with elevated progesterone levels and in particular with levels (>2.0 ng/mL) as this may lead to lower birth weight.

Citing Articles

The Effect of Progesterone Elevation on the Day of Trigger Administration: A Review of the Literature.

Jreij C, Halimeh R, Fadel D, Chamoun P, Nassar J, Saab W J Reprod Infertil. 2024; 25(2):102-109.

PMID: 39157800 PMC: 11327421. DOI: 10.18502/jri.v25i2.16005.

Association between serum hormone levels in early pregnancy and risk of hypertensive diseases of pregnancy in women undergoing assisted reproduction.

Martel R, Lee V, Armstrong A, Demirjian M, Kwan L, Al-Safi Z J Assist Reprod Genet. 2024; 41(9):2359-2366.

PMID: 39052170 PMC: 11405613. DOI: 10.1007/s10815-024-03212-8.

Progesterone levels during ovarian stimulation in segmented ART cycles inversely correlate with normalized birthweight of neonates conceived through subsequent frozen-thawed embryo transfer.

Quartucci A, Pagliardini L, Cavoretto P, Alteri A, Somigliana E, Dallagiovanna C J Assist Reprod Genet. 2023; 40(9):2109-2116.

PMID: 37395893 PMC: 10440326. DOI: 10.1007/s10815-023-02861-5.

Effect of serum progesterone on human chorionic gonadotropin trigger day / metaphase II oocyte ratio on pregnancy and neonatal outcomes in women undergoing ICSI cycle.

Huang L, Wan Q, Li T, Lv X, Geng L, He Q BMC Pregnancy Childbirth. 2023; 23(1):224.

PMID: 37016365 PMC: 10071741. DOI: 10.1186/s12884-023-05549-x.

Impact of Elevated Progesterone in Late Follicular Phase on Early Pregnancy Outcomes and Live Birth Rate After Fresh Embryo Transfers.

Xu Y, Zhang J, Li A, Yang N, Cui N, Hao G Front Cell Dev Biol. 2022; 10:855455.

PMID: 35372334 PMC: 8965638. DOI: 10.3389/fcell.2022.855455.

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