Progesterone Levels During Ovarian Stimulation in Segmented ART Cycles Inversely Correlate with Normalized Birthweight of Neonates Conceived Through Subsequent Frozen-thawed Embryo Transfer

Overview

Journal J Assist Reprod Genet

Publisher Springer

Specialties Genetics
Reproductive Medicine

Date 2023 Jul 3

PMID 37395893

Authors

Antonio Quartucci

Luca Pagliardini

Paolo Ivo Cavoretto

Alessandra Alteri

Edgardo Somigliana

Chiara Dallagiovanna

Paola Vigano

Annalisa Racca

Christophe Blockeel

Massimo Candiani

Enrico Papaleo

Valeria Stella Vanni

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate the association between serum progesterone (P) at the day of ovulation trigger and neonatal birthweight in singletons born after frozen-thawed embryo transfer in segmented ART cycles.

Methods: A retrospective multicenter cohort study involving data from patients who achieved uncomplicated pregnancy and term delivery of ART-conceived singleton babies following a segmented GnRH antagonist cycle. The main outcome was birthweight's z-score of the neonate. Univariate and multivariate linear logistic regression analyses were made to investigate the relation of z-score with variables inherent to the patient and to the ovarian stimulation. The variable P per oocyte was created by dividing the value of progesterone at ovulation trigger by the number of oocytes retrieved at oocyte retrieval.

Results: A total of 368 patients were included in the analysis. At univariate linear regression, the birthweight z-score of the neonate appeared to be inversely related to both P levels at the ovulation trigger (- 0.101, p = 0.015) and P levels per oocyte at trigger (- 1.417, p = 0.001), while it was directly related to the height of the mother (0.026, p = 0.002) and to the number of previous live births (0.291, p = 0.016). In multivariate analysis, both serum P (- 0.1; p = 0.015) and P per oocyte (- 1.347, p = 0.002) maintained the significant inverse association with birthweight z-score after adjusting for height and parity.

Conclusions: Serum progesterone level on the day of ovulation trigger inversely correlates with normalized birthweight of neonates in segmented GnRH antagonist ART cycles.

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