Non-coding RNAs, the Trojan Horse in Two-way Communication Between Tumor and Stroma in Colorectal and Hepatocellular Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Apr 11

PMID 28392501

Citations 22

Authors

Cristina- Sorina Catana

Martin Pichler

Gianluigi Giannelli

Robert M Mader

Ioana Berindan-Neagoe

Affiliations

Soon will be listed here.

Abstract

In a continuous and mutual exchange of information, cancer cells are invariably exposed to microenvironment transformation. This continuous alteration of the genetic, molecular and cellular peritumoral stroma background has become as critical as the management of primary tumor progression events in cancer cells. The communication between stroma and tumor cells within the extracellular matrix is one of the triggers in colon and liver carcinogenesis. All non- codingRNAs including long non-coding RNAs, microRNAs and ultraconserved genes play a critical role in almost all cancers and are responsible for the modulation of the tumor microenvironment in several malignant processes such as initiation, progression and dissemination. This review details the involvement of non codingRNAs in the evolution of human colorectal carcinoma and hepatocellular carcinoma in relationship with the microenvironment. Recent research has shown that a considerable number of dysregulated non- codingRNAs could be valuable diagnostic and prognostic biomarkers in cancer. Therefore, more in-depth knowledge of the role non- codingRNAs play in stroma-tumor communication and of the complex regulatory mechanisms between ultraconserved genes and microRNAs supports the validation of future effective therapeutic targets in patients suffering from hepatocellular and colorectal carcinoma, two distinctive entities which share quite a lot common non-coding RNAs.

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References

Panzitt K, Tschernatsch M, Guelly C, Moustafa T, Stradner M, Strohmaier H . Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology. 2007; 132(1):330-42. DOI: 10.1053/j.gastro.2006.08.026. View

Calin G, Liu C, Ferracin M, Hyslop T, Spizzo R, Sevignani C . Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell. 2007; 12(3):215-29. DOI: 10.1016/j.ccr.2007.07.027. View

E Wojcik S, Rossi S, Shimizu M, Nicoloso M, Cimmino A, Alder H . Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer. Carcinogenesis. 2009; 31(2):208-15. PMC: 2812567. DOI: 10.1093/carcin/bgp209. View

Gupta R, Shah N, Wang K, Kim J, Horlings H, Wong D . Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010; 464(7291):1071-6. PMC: 3049919. DOI: 10.1038/nature08975. View

Dong Y, Wu W, Wu C, Sung J, Yu J, Ng S . MicroRNA dysregulation in colorectal cancer: a clinical perspective. Br J Cancer. 2011; 104(6):893-8. PMC: 3065287. DOI: 10.1038/bjc.2011.57. View

Henry J, Azevedo-Pouly A, Schmittgen T . MicroRNA replacement therapy for cancer. Pharm Res. 2011; 28(12):3030-42. DOI: 10.1007/s11095-011-0548-9. View

Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S . Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma. Hepatology. 2011; 54(6):2064-75. DOI: 10.1002/hep.24614. View

Baraniskin A, Birkenkamp-Demtroder K, Maghnouj A, Zollner H, Munding J, Klein-Scory S . MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL. Carcinogenesis. 2012; 33(4):732-9. DOI: 10.1093/carcin/bgs020. View

Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R . HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 2012; 32(13):1616-25. PMC: 3484248. DOI: 10.1038/onc.2012.193. View

10.

Gutschner T, Diederichs S . The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 2012; 9(6):703-19. PMC: 3495743. DOI: 10.4161/rna.20481. View

11.

Lu M, Huang C, Pan M, Chen H, Hung W . Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9. Clin Cancer Res. 2012; 18(23):6416-25. DOI: 10.1158/1078-0432.CCR-12-0832. View

12.

Huang J, Guo Y, Zhao C, Yuan S, Wang Y, Tang G . Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin. Hepatology. 2012; 57(5):1882-92. DOI: 10.1002/hep.26195. View

13.

Yan X, Jia Y, Chen L, Zeng Q, Zhou J, Fu C . Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: role of the S100A4-miR155-SOCS1-MMP9 axis. Hepatology. 2013; 57(6):2274-86. DOI: 10.1002/hep.26257. View

14.

Kawaguchi T, Komatsu S, Ichikawa D, Morimura R, Tsujiura M, Konishi H . Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer. Br J Cancer. 2013; 108(2):361-9. PMC: 3566805. DOI: 10.1038/bjc.2012.546. View

15.

Yang F, Huo X, Yuan S, Zhang L, Zhou W, Wang F . Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell. 2013; 49(6):1083-96. DOI: 10.1016/j.molcel.2013.01.010. View

16.

Wang R, Zhao N, Li S, Fang J, Chen M, Yang J . MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42. Hepatology. 2013; 58(2):642-53. DOI: 10.1002/hep.26373. View

17.

Shen W, Zeng Z, Zhu W, Fu G . MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells. J Mol Med (Berl). 2013; 91(8):989-1000. DOI: 10.1007/s00109-013-1037-x. View

18.

Xie H, Ma H, Zhou D . Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma. Biomed Res Int. 2013; 2013:136106. PMC: 3674644. DOI: 10.1155/2013/136106. View

19.

Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis R . CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013; 23(9):1446-61. PMC: 3759721. DOI: 10.1101/gr.152942.112. View

20.

Lan S, Wu S, Zuchini R, Lin X, Su I, Tsai T . Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224. Hepatology. 2013; 59(2):505-17. PMC: 4298796. DOI: 10.1002/hep.26659. View