Weight Loss Independent Changes in Adipose Tissue Macrophage and T Cell Populations After Sleeve Gastrectomy in Mice

Overview

Journal Mol Metab

Specialty Cell Biology

Date 2017 Apr 6

PMID 28377871

Citations 19

Authors

Henriette Frikke-Schmidt

Brian F Zamarron

Robert W ORourke

Darleen A Sandoval

Carey N Lumeng

Randy J Seeley

Affiliations

Soon will be listed here.

Abstract

Objective: In addition to adipocytes, adipose tissue contains large numbers of immune cells. A wide range of evidence links the activity of these cells to regulation of adipocyte and systemic metabolic function. Bariatric surgery improves several aspects of metabolic derangements and at least some of these effects occur in a weight-loss independent manner. We sought to investigate the impact of vertical sleeve gastrectomy (VSG) on adipose immune cell frequencies.

Methods: We analyzed the frequencies of immune cells within distinct adipose tissue depots in obese mice that had VSG or sham surgery with a portion of the latter group pair-fed such that their body mass was matched to the VSG animals.

Results: We demonstrate that VSG induced a shift in the epididymal adipose tissue leukocyte profile including increased frequencies of CD11c macrophages, increased frequencies of T cells (CD4, CD8, and CD4/CD8 T cells all increased), but a significantly decreased frequency of adipose tissue dendritic cells (ATDC) that, despite the continued high fat feeding of the VSG group, dropped below control diet levels.

Conclusions: These results indicate that VSG induces substantial changes in the immune populations residing in the adipose depots independent of weight loss.

Citing Articles

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Influence of Donor-Specific Characteristics on Cytokine Responses in H3N2 Influenza A Virus Infection: New Insights from an Ex Vivo Model.

Huang C, Hsieh M, Wu Y, Huang P, Lin Y, Tsao K Int J Mol Sci. 2024; 25(20).

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T cells in obesity-associated inflammation: The devil is in the details.

Valentine Y, Nikolajczyk B Immunol Rev. 2024; 324(1):25-41.

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Vertical Sleeve Gastrectomy Offers Protection against Disturbed Flow-Induced Atherosclerosis in High-Fat Diet-Fed Mice.

Wei J, Lee W, Luo J, Huang H, Wang S, Chou R Int J Mol Sci. 2023; 24(6).

PMID: 36982743 PMC: 10051344. DOI: 10.3390/ijms24065669.

Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice.

Zhang W, Shi B, Li S, Liu Z, Li S, Dong S Front Endocrinol (Lausanne). 2023; 13:1041027.

PMID: 36636478 PMC: 9831654. DOI: 10.3389/fendo.2022.1041027.

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