Phosphorylation of LSD1 by PLK1 Promotes Its Chromatin Release During Mitosis

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2017 Mar 28

PMID 28344766

Citations 7

Authors

Bin Peng

Ruifeng Shi

Weiwei Jiang

Yue-He Ding

Meng-Qiu Dong

Wei-Guo Zhu

Xingzhi Xu

Affiliations

Soon will be listed here.

Abstract

Background: Lysine-specific histone demethylase 1 (LSD1) modulates chromatin status through demethylation of H3K4 and H3K9. It has been demonstrated that LSD1 is hyperphosphorylated and dissociates from chromatin during mitosis. However, the molecular mechanism of LSD1 detachment is unknown.

Results: In this report, we found that polo-like kinase 1 (PLK1) directly interacted with LSD1 and phosphorylated LSD1 at Ser-126 . Nocodazole-induced metaphase arrest promoted release of LSD1 from chromatin, and the phosphorylation-defective mutant LSD1 (S126A) failed to dissociate from chromatin upon nocodazole treatment.

Conclusions: Taken together, our findings demonstrate that phosphorylation of LSD1 at Ser-126 by PLK1 promotes its release from chromatin during mitosis.

Citing Articles

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