» Articles » PMID: 30866496

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer

Overview
Journal Cancers (Basel)
Publisher MDPI
Specialty Oncology
Date 2019 Mar 15
PMID 30866496
Citations 67
Authors
Affiliations
Soon will be listed here.
Abstract

Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy. Lysine-specific demethylase 1 (LSD1, also known as KDM1A), demethylates H3K4me1/2, or H3K9me1/2 in a context-dependent manner. In addition to the well-studied role of LSD1 in the epigenetic regulation of histone methylation changes, LSD1 regulates the methylation dynamic of several non-histone proteins and participates in the assembly of different long noncoding RNA (lncRNA_ complexes. LSD1 is highly expressed in various cancers, playing a pivotal role in different cancer-related processes. Here, we summarized recent findings on the role of LSD1 in the regulation of different biological processes in cancer cells through dynamic methylation of non-histone proteins and physical association with dedicated lncRNA.

Citing Articles

Lysine-specific demethylase 1a is obligatory for gene regulation during kidney development.

Kota S, Kota S bioRxiv. 2025; .

PMID: 40060432 PMC: 11888273. DOI: 10.1101/2025.02.25.640014.


Genome-wide analysis and expression profiling of the polyamine oxidase gene family in Solanum tuberosum L.

Miao X, Wang S, Wang Y, Cheng S, Wang X, Chen Y BMC Genomics. 2024; 25(1):1167.

PMID: 39623364 PMC: 11610100. DOI: 10.1186/s12864-024-10992-x.


LSD1 Demethylates and Destabilizes Autophagy Protein LC3B in Ovarian Cancer.

Li M, Feng J, Zhao K, Huang T, Zhang B, Yang Y Biomolecules. 2024; 14(11).

PMID: 39595554 PMC: 11591952. DOI: 10.3390/biom14111377.


Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation.

Poltronieri P Explor Target Antitumor Ther. 2024; 5(4):841-876.

PMID: 39280246 PMC: 11390297. DOI: 10.37349/etat.2024.00252.


The scaffolding function of LSD1 controls DNA methylation in mouse ESCs.

Malla S, Kumari K, Garcia-Prieto C, Caroli J, Nordin A, Phan T Nat Commun. 2024; 15(1):7758.

PMID: 39237615 PMC: 11377572. DOI: 10.1038/s41467-024-51966-7.


References
1.
Lanz R, McKenna N, Onate S, Albrecht U, Wong J, Tsai S . A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999; 97(1):17-27. DOI: 10.1016/s0092-8674(00)80711-4. View

2.
Shi Y, Lan F, Matson C, Mulligan P, Whetstine J, Cole P . Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004; 119(7):941-53. DOI: 10.1016/j.cell.2004.12.012. View

3.
Forneris F, Binda C, Vanoni M, Mattevi A, Battaglioli E . Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett. 2005; 579(10):2203-7. DOI: 10.1016/j.febslet.2005.03.015. View

4.
Metzger E, Wissmann M, Yin N, Muller J, Schneider R, Peters A . LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature. 2005; 437(7057):436-9. DOI: 10.1038/nature04020. View

5.
Shi Y, Matson C, Lan F, Iwase S, Baba T, Shi Y . Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005; 19(6):857-64. DOI: 10.1016/j.molcel.2005.08.027. View