» Articles » PMID: 28331813

Reproducibility of Biomedical Research - The Importance of Editorial Vigilance

Overview
Date 2017 Mar 24
PMID 28331813
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Many journal editors are a failing to implement their own authors' instructions, resulting in the publication of many articles that do not meet basic standards of transparency, employ unsuitable data analysis methods and report overly optimistic conclusions. This problem is particularly acute where quantitative measurements are made and results in the publication of papers that lack scientific rigor and contributes to the concerns with regard to the reproducibility of biomedical research. This hampers research areas such as biomarker identification, as reproducing all but the most striking changes is challenging and translation to patient care rare.

Citing Articles

Optimized bacterial absolute quantification method by qPCR using an exogenous bacterial culture as a normalization strategy in triple-species BV-like biofilms.

Lameira I, Pinto A, Lima A, Muzny C, Cerca N J Microbiol Methods. 2024; 219:106895.

PMID: 38331102 PMC: 11149788. DOI: 10.1016/j.mimet.2024.106895.


Development of Human Rhinovirus RNA Reference Material Using Digital PCR.

Ju D, Park D, Kim I, Kim S, Yoo H Genes (Basel). 2023; 14(12).

PMID: 38137032 PMC: 10742479. DOI: 10.3390/genes14122210.


Mathematical Modeling of Plasticity and Heterogeneity in EMT.

Tripathi S, Xing J, Levine H, Jolly M Methods Mol Biol. 2020; 2179:385-413.

PMID: 32939734 PMC: 8178376. DOI: 10.1007/978-1-0716-0779-4_28.


The use of digital pathology and image analysis in clinical trials.

Pell R, Oien K, Robinson M, Pitman H, Rajpoot N, Rittscher J J Pathol Clin Res. 2019; 5(2):81-90.

PMID: 30767396 PMC: 6463857. DOI: 10.1002/cjp2.127.


Priorities to Overcome Barriers Impacting Data Science Application in Emergency Care Research.

Puskarich M, Callaway C, Silbergleit R, Pines J, Obermeyer Z, Wright D Acad Emerg Med. 2018; 26(1):97-105.

PMID: 30019795 PMC: 6637965. DOI: 10.1111/acem.13520.


References
1.
Begley C, Ioannidis J . Reproducibility in science: improving the standard for basic and preclinical research. Circ Res. 2015; 116(1):116-26. DOI: 10.1161/CIRCRESAHA.114.303819. View

2.
Rao X, Huang X, Zhou Z, Lin X . An improvement of the 2ˆ(-delta delta CT) method for quantitative real-time polymerase chain reaction data analysis. Biostat Bioinforma Biomath. 2015; 3(3):71-85. PMC: 4280562. View

3.
. Raising standards. Nat Struct Mol Biol. 2013; 20(5):533. DOI: 10.1038/nsmb.2590. View

4.
Ioannidis J, Ntzani E, Trikalinos T, Contopoulos-Ioannidis D . Replication validity of genetic association studies. Nat Genet. 2001; 29(3):306-9. DOI: 10.1038/ng749. View

5.
. Journals unite for reproducibility. Nature. 2014; 515(7525):7. DOI: 10.1038/515007a. View