Epigallocatechin-3-gallate Inhibits Bacterial Virulence and Invasion of Host Cells

Overview

Journal Bioorg Med Chem

Specialties Biochemistry
Chemistry

Date 2017 Mar 23

PMID 28325635

Citations 9

Authors

Lun K Tsou

Jacob S Yount

Howard C Hang

Affiliations

Soon will be listed here.

Abstract

Increasing antibiotic resistance and beneficial effects of host microbiota has motivated the search for anti-infective agents that attenuate bacterial virulence rather than growth. For example, we discovered that specific flavonoids such as baicalein and quercetin from traditional medicinal plant extracts could attenuate Salmonella enterica serovar Typhimurium type III protein secretion and invasion of host cells. Here, we show epigallocatechin-3-gallate from green tea extracts also inhibits the activity of S. Typhimurium type III protein effectors and significantly reduces bacterial invasion into host cells. These results reveal additional dietary plant metabolites that can attenuate bacterial virulence and infection of host cells.

Citing Articles

Epigallocatechin gallate protects mice from ser. Typhimurium infection by modulating bacterial virulence through quorum sensing inhibition.

Cheng G, Jian S, Li W, Yan L, Chen T, Cheng T Front Cell Infect Microbiol. 2024; 14:1432111.

PMID: 39479281 PMC: 11521958. DOI: 10.3389/fcimb.2024.1432111.

Targeting bacterial pathogenesis by inhibiting virulence-associated Type III and Type IV secretion systems.

Blasey N, Rehrmann D, Riebisch A, Muhlen S Front Cell Infect Microbiol. 2023; 12:1065561.

PMID: 36704108 PMC: 9872159. DOI: 10.3389/fcimb.2022.1065561.

Research Progress on Small Molecular Inhibitors of the Type 3 Secretion System.

Lv C, Li Y, Wei Y, Wang J, Yu H, Gao F Molecules. 2022; 27(23).

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The Case against Antibiotics and for Anti-Virulence Therapeutics.

Hotinger J, Morris S, May A Microorganisms. 2021; 9(10).

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Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components.

Hotinger J, Pendergrass H, May A Biomolecules. 2021; 11(2).

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