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Specific Interactions Between Transcription Factors and the Promoter-regulatory Region of the Human Cytomegalovirus Major Immediate-early Gene

Overview
Journal J Virol
Publisher American Society for Microbiology
Date 1988 Mar 1
PMID 2828657
Citations 25
Authors
P Ghazal
H Lubon
L Hennighausen
Affiliations
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Abstract

Repeat sequence motifs as well as unique sequences between nucleotides -150 and -22 of the human cytomegalovirus immediate-early 1 gene interact in vitro with nuclear proteins. We show that a transcriptional element between nucleotides -91 and -65 stimulated promoter activity in vivo and in vitro by binding specific cellular transcription factors. Finally, a common sequence motif, (T)TGG/AC, present in 15 of the determined binding sites suggests a particular class of nuclear factors associated with the immediate-early 1 gene.

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