Towards Patient-specific Modelling of Lesion Formation During Radiofrequency Catheter Ablation for Atrial Fibrillation

Overview

Journal Annu Int Conf IEEE Eng Med Biol Soc

Specialty Biomedical Engineering

Date 2017 Mar 7

PMID 28261003

Citations 2

Authors

Navjeevan Soor

Ross Morgan

Marta Varela

Oleg V Aslanidi

Affiliations

Soon will be listed here.

Abstract

Radiofrequency catheter ablation procedures are a first-line method of clinical treatment for atrial fibrillation. However, they suffer from suboptimal success rates and are also prone to potentially serious adverse effects. These limitations can be at least partially attributed to the inter- and intra- patient variations in atrial wall thickness, and could be mitigated by patient-specific approaches to the procedure. In this study, a modelling approach to optimising ablation procedures in subject-specific 3D atrial geometries was applied. The approach enabled the evaluation of optimal ablation times to create lesions for a given wall thickness measured from MRI. A nonliner relationship was revealed between the thickness and catheter contact time required for fully transmural lesions. Hence, our approach based on MRI reconstruction of the atrial wall combined with subject-specific modelling of ablation can provide useful information for improving clinical procedures.

Citing Articles

Modeling Left Atrial Flow, Energy, Blood Heating Distribution in Response to Catheter Ablation Therapy.

Dillon-Murphy D, Marlevi D, Ruijsink B, Qureshi A, Chubb H, Kerfoot E Front Physiol. 2019; 9:1757.

PMID: 30618785 PMC: 6302108. DOI: 10.3389/fphys.2018.01757.

A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research.

Ni H, Morotti S, Grandi E Front Physiol. 2018; 9:958.

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