Pathological Overproduction: the Bad Side of Adenosine

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 2017 Mar 3

PMID 28252203

Citations 60

Authors

Pier Andrea Borea

Stefania Gessi

Stefania Merighi

Fabrizio Vincenzi

Katia Varani

Affiliations

Soon will be listed here.

Abstract

Adenosine is an endogenous ubiquitous purine nucleoside, which is increased by hypoxia, ischaemia and tissue damage and mediates a number of physiopathological effects by interacting with four GPCRs, identified as A , A , A and A . Physiological and acutely increased adenosine is mostly associated with beneficial effects that include vasodilatation and a decrease in inflammation. In contrast, chronic overproduction of adenosine occurs in important pathological states, where long-lasting increases in the nucleoside levels are responsible for the bad side of adenosine associated with chronic inflammation, fibrosis and organ damage. In this review, we describe and critically discuss the pathological overproduction of adenosine and analyse when, where and how adenosine exerts its detrimental effects throughout the body.

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