Surfactant-stripped Naphthalocyanines for Multimodal Tumor Theranostics with Upconversion Guidance Cream

Overview

Journal Nanoscale

Specialty Biotechnology

Date 2017 Mar 2

PMID 28247896

Citations 14

Authors

Yumiao Zhang

Hao Hong

Boyang Sun

Kevin Carter

Yiru Qin

Wei Wei

Depeng Wang

Mansik Jeon

Jumin Geng

Robert J Nickles

Guanying Chen

Paras N Prasad

Chulhong Kim

Jun Xia

Weibo Cai

Jonathan F Lovell

Affiliations

Soon will be listed here.

Abstract

Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.

Citing Articles

Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer.

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Theranostic Phthalocyanine and Naphthalocyanine Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Tumors.

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