Dragon Fruit-like Biocage As an Iron Trapping Nanoplatform for High Efficiency Targeted Cancer Multimodality Imaging

Overview

Journal Biomaterials

Specialty Biomedical Engineering

Date 2015 Aug 16

PMID 26275860

Citations 22

Authors

Min Yang

Quli Fan

Ruiping Zhang

Kai Cheng

Junjie Yan

Donghui Pan

Xiaowei Ma

Alex Lu

Zhen Cheng

Affiliations

Soon will be listed here.

Abstract

Natural biopolymer based multifunctional nanomaterials are perfect candidates for multimodality imaging and therapeutic applications. Conventional methods of building multimodal imaging probe require either cross-linking manners to increase its in vivo stability or attach a target module to realize targeted imaging. In this study, the intrinsic photoacoustic signals and the native strong chelating properties with metal ions of melanin nanoparticle (MNP), and transferrin receptor 1 (TfR1) targeting ability of apoferritin (APF) was employed to construct an efficient nanoplatform (AMF) without tedious assembling process. Smart APF shell significantly increased metal ions loading (molar ratio of 1:800, APF/Fe(3+)) and therefore improved magnetic resonance imaging (MRI) sensitivity. Moreover, synergistic use of Fe(3+) and APF contributed to high photoacounstic imaging (PAI) sensitivity. AMF showed excellent bio-stability and presented good in vivo multimodality imaging (PET/MRI/PAI) properties (good tumor uptake, high specificity and high tumor contrast) in HT29 tumor because of its targeting property combined with the enhanced permeability and retention (EPR) effect, making it promising in theranostics and translational nanomedicine.

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