Mitochondrial Homeostasis in Adipose Tissue Remodeling

Overview

Journal Sci Signal

Specialties Cell Biology
Physiology
Science

Date 2017 Mar 2

PMID 28246203

Citations 42

Authors

Svetlana Altshuler-Keylin

Shingo Kajimura

Affiliations

Soon will be listed here.

Abstract

Mitochondrial homeostasis is regulated by a balance between mitochondrial biogenesis and degradation. Emerging evidence suggests that mitophagy, a selective form of autophagy that degrades mitochondria, plays a key role in the physiology and pathophysiology of mitochondria-enriched cells, such as brown and beige adipocytes. This review discusses findings regarding the roles of autophagy and mitophagy in cellular development, maintenance, and functions of metabolic organs, including adipose tissue, liver, and pancreas. A better understanding of the molecular links between mitophagy and energy metabolism will help to identify promising targets for the treatment of obesity and obesity-associated disorders.

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Editorial: Novel regulatory mechanisms behind thermogenesis of brown and beige adipocytes.

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