M2 Macrophages Independently Promote Beige Adipogenesis Via Blocking Adipocyte Ets1

Overview

Journal Nat Commun

Specialty Biology

Date 2024 Feb 22

PMID 38388532

Authors

Suyang Wu

Chen Qiu

Jiahao Ni

Wenli Guo

Jiyuan Song

Xingyin Yang

Yulin Sun

Yanjun Chen

Yunxia Zhu

Xiaoai Chang

Peng Sun

Chunxia Wang

Kai Li

Xiao Han

Affiliations

Soon will be listed here.

Abstract

Adipose tissue macrophages can promote beige adipose thermogenesis by altering local sympathetic activity. Here, we perform sympathectomy in mice and further eradicate subcutaneous adipose macrophages and discover that these macrophages have a direct beige-promoting function that is independent of sympathetic system. We further identify adipocyte Ets1 as a vital mediator in this process. The anti-inflammatory M2 macrophages suppress Ets1 expression in adipocytes, transcriptionally activate mitochondrial biogenesis, as well as suppress mitochondrial clearance, thereby increasing the mitochondrial numbers and promoting the beiging process. Male adipocyte Ets1 knock-in mice are completely cold intolerant, whereas male mice lacking Ets1 in adipocytes show enhanced energy expenditure and are resistant to metabolic disorders caused by high-fat-diet. Our findings elucidate a direct communication between M2 macrophages and adipocytes, and uncover a function for Ets1 in responding to macrophages and negatively governing mitochondrial content and beige adipocyte formation.

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