WNK Kinases in Development and Disease

Overview

Journal Curr Top Dev Biol

Publisher Elsevier

Specialties Biology
Reproductive Medicine

Date 2017 Feb 27

PMID 28236964

Citations 29

Authors

Aylin R Rodan

Andreas Jenny

Affiliations

Soon will be listed here.

Abstract

WNK (With-No-Lysine (K)) kinases are serine-threonine kinases characterized by an atypical placement of a catalytic lysine within the kinase domain. Mutations in human WNK1 or WNK4 cause an autosomal dominant syndrome of hypertension and hyperkalemia, reflecting the fact that WNK kinases are critical regulators of renal ion transport processes. Here, the role of WNKs in the regulation of ion transport processes in vertebrate and invertebrate renal function, cellular and organismal osmoregulation, and cell migration and cerebral edema will be reviewed, along with emerging literature demonstrating roles for WNKs in cardiovascular and neural development, Wnt signaling, and cancer. Conserved roles for these kinases across phyla are emphasized.

Citing Articles

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