Detection of Varicella-zoster Virus Nucleic Acid in Neurons of Normal Human Thoracic Ganglia

Overview

Journal Ann Neurol

Specialty Neurology

Date 1987 Sep 1

PMID 2823688

Citations 40

Authors

D H Gilden

Y Rozenman

R Murray

M Devlin

A Vafai

Affiliations

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Abstract

Tissue sections from four normal human thoracic ganglia were hybridized in situ with a varicella-zoster virus-RNA probe. Varicella-zoster virus was detected in two of four ganglia, localized exclusively in neurons. The detection of latent varicella-zoster virus genetic material in thoracic ganglia provides further evidence of varicella-zoster virus latency at multiple levels of the human neuraxis and supports the notion that the neuron is the primary site of herpesvirus latency.

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