Effect of Vitamin E on FMLP-induced Activation of Rabbit Polymorphonuclear Leukocytes

Overview

Journal Inflammation

Specialties Allergy & Immunology
Pathology

Date 1987 Sep 1

PMID 2820879

Citations 1

Authors

S J Weisman

J E Lafuze

R A Haak

R L Baehner

Affiliations

Soon will be listed here.

Abstract

Granulocytes of vitamin E-treated rabbits were compared to granulocytes from placebo-treated rabbits. Granulocytes were isolated from rabbit peripheral blood by a new method employing Percoll and gelatin sedimentation. Vitamin E-treated cells showed less adherence to rabbit aortic endothelium when stimulated with FMLP. FMLP receptor numbers and affinity were not significantly different. Resting cell surface and baseline transmembrane potential were similar in both cell types. Decrease in cell surface potential with FMLP was comparable in vitamin E- and placebo-treated cells. Vitamin E-treated PMN depolarized more and hyperpolarized more rapidly than placebo cells. Thus vitamin E-treated PMNs show differences in the early events of PMN activation. These may contribute to the lower stimulated adherence observed with vitamin E-treated cells.

Citing Articles

Profiling oxidative stress markers and cardiovascular complications in chronic kidney disease patients supplemented with vitamin E.

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